1.1.2014 Flashcards
adverse effects of rapid admn of fosphenytoin
arrythmia
CVS collapse
coma
fetal hydantoin syndrome
cleft lip
cleft palate
congenital heart disease
adverse effects of phenytoin
gum hypertrophy hirsuitism coarsening of facial features megaloblastic anemia VitD deficiency VitK deficiency hyperglycemia
QUININE IS gametocidal agnst
vivax and ovale
not against falciparum
5’ de iodinase is found in
liver
kidney
brain
pitutary
only indication for T3
myxedema coma
drugs inhibiting iodine uptake
thiocyanate
perchlorate
drugs inhibiting thyroid hormone secretion
NaI
KI
Li
Drugs inhibiting peripheral conversion
PTU
propranolol
amiodarone
time to effect of antithyroid action of PTU,methimazole,carbimazole
1-3 wks
till stores are used up
most common adverse effects of antithyroid drugs
maculopapular rash
most serious adverse effect of antithyroid drugs
reversible agranulocytosis
fastest acting antithyroid drugs
iodides
contraindications for I131
age<35 yrs
pregnancy
co existing ophthalmopathy
graves ophthalmopathy is aggravated by
thiazelidenidiones
I131