8) Pharmacy Flashcards
Why might depression be more common in older people (1 in 5)?
Co-morbid conditions
Not functioning how they used to
What is the epidemiology of mental health disorders in prisons?
9 in 10 have a mental health disorder
Which gender is more likely to commit suicide?
Male
Why does depression need to be treated?
Risk of mortality
High morbidity
Describe the stepped care model for treating depression:
Based on severity of depression, there are different steps to treating. From assessment, to medication and therapy to ECT
Give some examples of SSRIs:
Citalopram
Fluoxetine
Escitalopram
Sertraline
What is the mechanism of SSRIs?
Block reuptake of serotonin into pre-synaptic neurones, increasing serotonin in synaptic cleft
What are some side effects of SSRIs?
Nausea Erectile dysfunction Weight loss Agitation Sleep disturbance
What are the main interactions in terms of antidepressants?
SSRI and NSAID - increased risk of bleeding
Citalopram and antipsychotics - increased risk of QT prolongation
Give some examples of TCAs:
Amitriptyline
Clomipramine
What is the mechanism of TCAs?
Blocking reuptake of NA and serotonin into pre-synaptic neurones
What side effect caused TCAs to be phased out?
Cardiotoxic in overdose
What are MAOIs and how do they work?
Monoamine oxidase inhibitors
Irreversibly inhibiting action of monoamine oxidase which breaks down NA and serotonin
Give some examples of MAOIs:
Phenelzine
Trancypromine
What are some side effects of MAOIs?
Nausea
Constipation
Hypertension
