8. Inappropriate activation of the immune system

Question 1

Immune reactant of type 1 response and antigen

Answer 1

IgE

Soluble antigen

Question 2

Immune reactant of type II response

Answer 2

IgG

Cell/matrix associated antigen or cell surface receptor

Question 3

Immune reactant of type III response

Answer 3

IgG

Soluble antigen

Question 4

Immune reactants of type IV response

Answer 4

Th1 Th2 - soluble antigen

CTL - cell associated antigen

Question 5

Type I effector mechanism

Answer 5

Mast cell activation

Question 6

Type II effector mechanisms

Answer 6

for cell/matrix associated antigen - complement

for cell surface receptor - antibody alters signalling

Question 7

Type III effector mechanism

Answer 7

Complement, phagocytes

Question 8

Type IV effector mechanisms

Answer 8

Th1 - macrophage activation
Th2 - IgE production, eosinophil activation
CTL - cytotoxicity

Question 9

Example of type I

Answer 9

allergic asthma

allergic rhinitis

Question 10

Example of type II

Answer 10

drug allergies e.g. penicillin
chronic urticaria (cell surface receptor)

Question 11

Example of type III

Answer 11

serum sickness

arthus reaction

Question 12

Example of type IV

Answer 12

Th1 - allergic contact dermitis
Th2 - chronic asthma
CTL- craft rejection

Question 13

Treatment which targets mediator action

Answer 13

antihistamines

beta blockers

Question 14

Treatment which targets chronic inflammatory reactions

Answer 14

corticosteroids

Question 15

Treatment which targets Th2 response

Answer 15

Desensitisation therapy by injections of specific antigen

Question 16

Treatment which targets IgE binding to mast cell

Answer 16

Anti IgE antibodies (omalizumab)

Question 17

Organ specific autoimmune disorders

Answer 17

TIDM
MS
Crohn’s disease
psoriasis

Question 18

System specific autoimmune disorders

Answer 18

arthritis
scleroderma
polymyositis

Question 19

Type II autoimmune diseases

Answer 19

Autoimmune haemolytic anaemia

Acute rheumatic fever

Question 20

Treatments for crohn’s

Answer 20

Aminosalicylates
Corticosteroids
Immunosuppressants
Biologics like infliximab, certolizumab, natalizumab