5. B cell development and the activation of plasma cells Flashcards
1
Q
Essential for formation of the common lymphoid progenitor
A
Interaction of FLT3 and FLT3 ligand
2
Q
What does the stroll cell produce to induce MPC to LPC
A
IL7
3
Q
What drives the cells intro cell division in late pro B
A
the tyrosine kinase receptor Kit binds its ligand stem cell factor, SCF, activating the kinase and driving the cells into cell division
4
Q
what acts as a surrogate light chain after heavy chain rearrangement
A
VpreB and lambda 5
5
Q
Which signal molecules also help binding of pre B receptor to the membrane and prevent further H chain rearrangements?
A
Ig alpha and Ig beta
6
Q
What does a T cell product to activate B cells
A
CD40L
Cytokines IL 4, 5, 6
