1. Basic concepts in immunology Flashcards
What are the 4 main tasks of the immune system?
- Immunological recognition
- Immunological effector function/response
- Immunological Regulation
- Immunological Memory
What do macrophages release in the inflammatory response?
Cytokines and chemokines
What do cytokines and chemokine cause in the inflammatory response?
Vasodilation and increased vascular permeability which causes redness, heat and swelling.
What are some PRRs of macrophages? 5
LPS receptor - recognises lipopolysaccharides
Scavenger receptor - recognises carbohydrates on cell walls
TLR2 - Gram + bacteria
TLR4 - Gram - bacteria
Mannose receptor
Which 2 granulocytes are involved in allergic response?
Mast cells and basophils
Which type of immunity do NK cells partake in?
innate immunity
What percentage of lymphocytes are T and B cells
20% B cells 80% T cells
What are the 4 principles of clonal selection?
Specificity
Affinity activation
Effector specificity
Deletion
Where are mostly T cells found in the lymph node?
the paracortical area
Where are B cells found in the lymph node?
lymphoid follicles
