8 - Generation of Cell-mediated Effector Mechanisms

Question 1

Principal CK that enhance phagocytic function. Who produces it? What others CK’s also activate phagocytes?

Answer 1

TH1 ▶️ IFN-gamma ▶️ (+) Phagocytes

Also TNF-Alfa, TNF-Beta

Question 2

What antibodies isotypes can stimulate antibody-dependent cell-mediated cytotoxicity? What mechanism can elicit it?

Answer 2

IgG (recognition in Fc portion by Eo, Neu, Macro, NK)
IgE ▶️ when target is parasitic worm
Lytic enzymes, TNF, perforins

Question 3

CK’s that activate NK cells, where are they come from?

Answer 3

TH1 citokines (IFN-gamma, IL-2, TGFB)
INF (Alfa y beta) during viral infections
IL-12 by macrophages (activated by TH1)

Question 4

What type of cells are in charge of immune surveillance of tumors?

Answer 4

CTL, NK cells

Question 5

What parameters about immune function would be altered if ablation of thymus is carried out?

Answer 5

Immune surveillance of tumors
Response to intracellular pathogens
Secondary antibody response

Question 6

Principal CK stimulation of the CTL?

Answer 6

TH1 ▶️ IL-2

Question 7

Which citokine increase the platelet count? Medical use.

Answer 7

IL-11

Treatment in thrombocytopenia

Question 8

Treatment for chronic granulomatous disease?

Answer 8

IFN-gamma