10 - Vaccination and Immunotherapy

Question 1

Risks of use passive immunotherapy

Answer 1

• IgE production
• type III hypersensibility reaction
• anti-allotype antibodies

Question 2

Vaccine contraindicated in pregnancy

Answer 2

Rubella (MMR)

Question 3

Vaccines contraindicated in patients with egg allergy

Answer 3

Influenza

Yellow fever

Question 4

What age is appropriate to begin giving attenuated live vaccines? Why?

Answer 4

Since 12 mo age

Persistence Maternal Ig can inhibit replication ▶️ fail vaccine

Question 5

Why are some vaccines conjugated? And which are some of them?

Answer 5

T-cell dependent vaccines: capsular polysaccharide from bacteria (hapten, CHO) + conjugated (carrier protein) ▶️ T-cell recognition of protein carrier provides the necessary to (+) TH ▶️ switch ab (IgG, IgA), memory

S. pneumoniae, N. meningitidis, H. influenza ▶️ most of all under 5 age

Question 6

Which Ig is used to diagnose infections in neonate?

Answer 6

IgM

*IgG can’t know where come from, maternal IgG may persist 6-12 mo

Question 7

When is usually made the diagnose of a some immunodeficiency in a infant?

Answer 7

After 12 mo

*persistence of maternal IgG that confers protection. May be more time because IgA from colostrum.

Question 8

Type of response that attenuated (live) vaccines elicit

Answer 8

CMI, HMI - cellular and humoral mediated immunity

Question 9

Type of response that killed viral vaccines may elicit

Answer 9

Humoral mediated immunity (HMI)

Question 10

Minor amino-acid sequence variations in the constant domains of heavy and light immunoglobulin chains

Answer 10

Allotype