5 - The First Response to Antigen

Question 1

Which molecule mediates the tight binding between leukocytes and endothelium to promote transendothelial migration into areas of injury?

Answer 1

Integrins

*on the leukocytes to immunoglobulin-superfamily cellular adhesion molecules on the endothelium

Question 2

How is hypochlorite generated inside the phagolysosome?

Answer 2

From myeloperoxidase

Question 3

Absence of CD18, what disease does it lead? Function of the molecule?

Answer 3

Leukocyte adhesion deficiency

B2 chain of some integrin molecules

Question 4

Role of Protein A of staphylococcus aureus

Answer 4

Block opsonization ▶️ binding to the Fc component of IgG

Question 5

Some mechanism of intracellular killing oxygen-independent

Answer 5

At lysosomes: lysozyme, defensins, lactoferrin, hydrolytic enzymes

Question 6

Types of microorganism with higher risk of severe chronic, recurrent infection in chronic granulomatous disease. Cause.

Answer 6

Catalase (+) ex; staphylococcus, serratia, klebsiella, aspergillus
Inherited Deficiency of NADPH oxidase ▶️ ⬇️ oxygen-dependent metabolites

Question 7

Diagnostic test for chronic granulomatous disease. How is it interpreted?

Answer 7

Nitroblue tetrazolium reduction test (NBT)
Formazan (+) ▶️ purple-blue ▶️ Normal
Formazan (-) ▶️ yellow ▶️ abnormal

Question 8

Consequence of IL-4 deficiency

Answer 8

• defects in ability to mount an IgE response

- as major stimulus for TH2 development ▶️ effects in all aspects of the secondary antibody response

Question 9

Consequences of C3 deficiency

Answer 9

⬆️ susceptibility to pyogenic infections and extracellular organisms

*C3b opsonin for extracellular organisms