Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Mercy CLS 1: Immunology > 8) Autoimmune diseases > Flashcards

8) Autoimmune diseases Flashcards

1
Q

predispositions to autoimmune conditions

A
  • genetics
  • female
  • age
  • mental state/stress
  • infections
  • drugs
  • other autoimmune diseases
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

2 drugs that predispose pt to autoimmune disease

A

procainamide
hydralazine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

how can trauma and infection predispose pt to autoimmune disease

A

release sequestered antigens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

possible mechanisms of autoimmune disease

A
  • loss of suppressor T cells
  • MHC genes for molecules on cells they should not be on
  • idiotypic networks (ab against ab)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

example of an idiotypic network

A

RF

IgM against IgG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

examples of disease with anti-idiotypic networks

A

myasthenia gravis
DM
Grave’s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

organ systems affected by SLE

A

joints
CNS
heart
kidneys

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

cause of death in SLE

A

kidney lesions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

type of scleroderma with increased collagen deposits in skin

A

progressive systemic sclerosis (PSS)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

associated with Raynaud’s phenomenon

A

PSS
CREST

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

CREST syndrome

A
  • calcinosis
  • raynaud’s
  • esophageal dysfunction
  • sclerodactyly
  • telengiectasis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

components that attack joint spaces in RA

A

RFs
cytokines
IgG complexes
neutrophils
hyaluronidase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

connective tissue disease with no renal involvement (5% pts may have it)

A

mixed connective tissue disorder (MCTD)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

2 Ab involved in pernicious anemia

A

IF-blocking Ab
parietal cell Ab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

autoimmune hepatitis involving smooth muscle Ab

A

chronic active hepatisis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

very dry mouth, eyes, nose, trachea, bronchi, vagina, skin

large parotid glands

A

Sjogren’s syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

T-cells infiltrate muscle and cause inflammation

A

polymyositis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

predominantly in young males

A

Goodpasture

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

glomerulonephritis
pulmonary hemorrhage
Ab to basement membrane of lungs, kidneys

A

Goodpasture

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

necrotizing granulomas in resp tract
focal glomerulonephritis

A

Wegener’s granulomatosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

2 autoimmune conditions involving skin blisters

A

bullous pemphigoid
pemphigus vulgaris

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

mitrochondrial Ab
bile ducts of liver slowly destroyed
liver damage

A

primary biliary cirrhosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

increased risk of clotting and repeated spontaneous abortions

A

anti-phospholipid syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

goiter
hypothyroidism

A

Hashimoto’s thyroiditis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
goiter ophthalmopathy localized edema in legs hyperthyroidism
Graves
23
2 types of anti-TSH receptor Ab
- stimulates action of TSH on thyroid - blocks action of TSH on thyroid
24
Ab to NM junction (Ach receptor Ab) weakness and fatigue of skeletal muscles
myasthenia gravis
25
causes most damage in MS
T-cells
26
autoab to plt
idiopathic/immune thrombocytopenia purpura
27
linear deposits of IgG/C3 at dermal-epidermal junction
bullous pemphigoid
28
honeycomb pattern of IgG/C3 in skin intercellular spaces
pemphigus vulgaris
29
ribbonlike pattern of Ab/C3 along glomerular basement membrane
Goodpasture SLE
30
general indirect IFA autoimmune screen
ANA anti nuclear Ab
31
3 Abs detected with mouse stomach-kidney substrate
- AMA (anti mitochondrial) - ASMA (anti smooth muscle) - APCA (anti parietal cell)
32
ANCA
anti neutrophil cytoplasmic ab
33
ANA test substrate & 5 patterns
**HEP-2** (human epithelials in interphase/mitosis) - homogeneous - speckled - centromere - nucleolar - rim/peripheral
34
entire nucleus fluoresces mitotic cells pos
homogeneous
35
homogeneous pattern suggests...
ab to nDNA reflex to anti-nDNA
36
homogeneous pattern diseases
SLE drug-induced SLE (Ab to histones, ssDNA)
37
many uniform points of fluorescence mitotic cells neg
speckled
38
speckled pattern suggests....
Ab to an extractable nuclear antigen (ENA) reflex to ENA test
39
medium size points of fluorescence mitotic cells pos in ladder-like pattern
centromere
40
centromere pattern disease
CREST syndrome
41
intense fluorescence of nucleoli mitotic cells pos
nucleolar pattern
42
nucleolar pattern diseases
PSS SLE
43
nucleus fluoresces around edge only
rim/peripheral pattern
44
rim pattern suggests...
ab to nDNA
45
rim pattern disease
SLE (most specific)
46
anti-nDNA substrate
crithidia lucillae
47
positive result in anti-nDNA test
fluorescence of kinetoplast of C. lucillae organism
48
positive anti-nDNA test diseases
active SLE nephritis
49
nDNA Ab titer correlates with...
renal involvement
50
fluorescence of kidney tubules + parietal cells ab and disease
AMA primary biliary cirrhosis
51
fluorescence of stomach muscularis and vessel walls ab and disease
ASMA chronic active hepatitis
52
fluorescence of parietal cells ab and disease
APCA pernicious anemia
53
2 ANCA patterns
- C-ANCA - fluorescence of cytoplasm - P-ANCA - fluorescence of perinuclear region
54
ANCA substrate
human neutrophils
55
C-ANCA disease
Wegener's granulomatosis
56
P-ANCA disease
systemic vasculitis
57
explain EIA
solid phase + Ag + pt Ab + conjugate + enzyme + chromogenic substrate ==> color change
58
enzyme tag often on conjugate for EIA
horseradish peroxidase
59
EIA reading
spectrophotometric
60
ENAs and disease associations
- **Sm (Smith)** - SLE - **RNP (ribonucleoprotein)** - MCTD, SLE - **SS-A (Ro)** - Sjogren's, scleroderma, SLE, neonatal lupus - **SS-B (La)** - Sjogren's, scleroderma, SLE - **Scl-70** - PSS - **PM-1** - polymyositis, SLE - **Jo-1** - polymyositis
61
associated with DVT, arterial thrombosis, spontaneous abortion
anti-PL ab (LLAC, anti-cardiolipin)
62
seen in 90% of Hashimoto's pts and 80% of Graves pts
thyroid peroxidase ab (TPO) (microsomal ab)
63
seen in 60-80% of Hashimoto pts
thyroglobulin antibody (TGAB)
64
>98% pts with Graves have...
thyroid stimulating Ig (TSI)
65
performed instead of expensive TPI test
TH levels
66
ideally use both ..... to dx RA
RF and anti-CCP
67
found in 75% pts with RA, but not specific for RA
RF
68
Ab against citrullinated peptides formed during death of grans and macros
anti-CCP
69
more specific for RA than RF
anti-CCP
70
ANAs are present in 40% of ----- pts but significance is unknown
RA

Mercy CLS 1: Immunology (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions