8 Anesthesia Flashcards
Concerning findings on airway exam for anesthesia?
BMI >31
Interincisor or intergingival distance >3cm
Class III or IV mallampati classification
Inability to protrude lower incisors to meet or extend past upper incisors
Radiation changes or thick obese neck
Limited extension or possible unstable cervical spine
Presence of full beard
Mallampati classification of the airway
Class I - Can see everything
Class II - cannot see all of pillars or uvula
Class III - cannot see pillars
Class IV - Cannot see anything
MAC
Minimum alveolar concentration - smallest conc of inhalation agent at which 50% of patients will not move with incision
Small MAC - more lipid soluble = more potent
Speed of induction is inversely proportion to solubility
Common AE for inhaled anesthetics?
Unconsciousness, amnesia, analgesia
Blunt hypoxic drive
Myocardial depression, increase cerebral blood flow and decrease renal blood flow
Nitrous oxide
Fast
Minimal myocardial depression
Tremors at induction
Halothane
Slow onset/offset
Highest degree of cardiac depression and arrhythmias
Least pungent - good for children
Halothane hepatitis
Fever
eosinophilia
Jaundice
Increased LFTs
Sevoflurane
Fast
Less laryngospasm
Less pungent
Good for mask induction
Isoflurane
Good fro neurosurgery - lowers brain consumption, no increase in ICP
Enflurane
Can cause seizures
Sodium thiopental
Barbiturate
Fast acting
AE: decreased cerebral blood flow and metabolic rate; decreased blood pressure
Propofol
Very rapid distribution and on/off
Amnesia, sedative, NOT analgesic
AE: Hypotension, respiratory depression, egg allergy
Metabolized in liver and by plasma cholinesterases
Ketamine
Dissociation of thalamic/limbic systems Cataleptic state (amnesia, analgesia) AE: Hallucinations, catecholamine release (increased CO2, tachycardia), increased airway secretions, increased cerebral blood flow CI: head injury Good for children
Etomidate
Fewer hemodynamic changes
Fast acting
Continuous infusions can lead to adrenocortical suppression
What is the last muscle to go down and first muscle to recovery from paralytics?
Diaphragm
What is the first muscle to go down and last muscle to recover from paralytics?
Neck muscles and face
Succinylcholine
Fast, short acting
AE: Fasciculations, increase ICP, malignant hyperthermia
CI: Hyperkalemia, open-angle glaucoma, atypical pseudocholinesterases
Malignant hyperthermia
Defect in calcium metabolism
Calcium release from sarcoplasmic reticulum causes muscle excitation-contraction syndrome
AE: increase ETCO2, fever, tachycardia, rigidity, acidosis, hyperkalemia
Treatment: dantrolene, cooling blankelts, HOC3, glucose, supportive care
What is the first sign of malignant hyperthermia?
Increased ETCO2
Dantrolene - MOA, dose
Inhibits Ca release and decouples excitation complex
Dose 10mg/kg
Hyperkalemia and succinylcholine
Depolarization release more K
CI: Severe burns, neurologic injury, neuromusclar disorders, spinal cord injury, massive trauma, acute renal failure
Atypical pseudocholinesterases and succinylcholine
Causes prolong paralysis
Seen in Asians
Non-depolarizing paralytic agents
Inhibit neuromuscular junctions by competing with acetylcholine
Get prolongation of these agents with myasthenia graves
Cis-atracurium
Hoffman degradation
Can be used in liver and renal failure
Causes histamine release
Rocuronium
Fast, intermediate duration
Hepatic metabolism
Pancuronium
Slow acting, long-lasting
Renal metabolism
AE: tachycardia
Neostigmine
Edrophonium
Blocks acetylcholinesterase, increasing acetylcholine
Reversing drugs for non-depolarizing agents
Neostigmine
Edrophonium
Atropine/glycopyrrolate - given with to counteract the effects of generalized acetylcholine overdose
MOA - local anesthetics
Works by increasing action potential, preventing Na influx