8. Acquired hemolytic anemia: classification, clinical manifestation, diagnosis, treatment.

Question 1

autoimmune hemolytic anemi can be divided into ?

Answer 1

it is usally a chronic hemolytc aneia

warm type
IgG - human bod temp 37 degrees
their destruction in the spleen = extravascular hemolysisi
= due to idiopathic , penicllin or in children preceeding vral infections

cold type
IgM binding to rbc at 0-10 degrees
= intravascular hemlysisi

if acute form of disease called = paroxysmal cold hemoglobinurea
occurs in children
viral pneumoonia or mycoplasma is the cause

Question 2

what isthe diagnosisi of acuquired autoimmnue hemolytic anemia ?

Answer 2

cbc
normocytic anemia

direct coomb’s test
psotive test = hemoagglutination

or direct antigen test

Question 3

what is the signs and symptoms for acquired hemolytic anemia ?

Answer 3

enlargened spleen

anemic signs

jaundice

Question 4

what type of anemia is autoimmune hemolytic anemia ?

Answer 4

it is an NORMOCYTIC ANEMIA

Question 5

treatmnet of acquired autoimmune heolytic anemia

Answer 5

blood trasnfusion
generally when hemoglobin is less than 7 g/dl

warm
steroids
immunosuppresions - azathioprine and cyclosporin a
monoclonal antibodes against autoanitbodies

cold
n treatmnet usually required