5. Extravascular and intravascular hemolysis: causes, pathophysisology, Flashcards

1
Q

WHAT ARETHE CAUSES FOR HEMOLYSISI ?

A
generally classified into inherited (coprsular) 
thalessemia 
sickle cell anemia 
hemoglobin c 
G6P- deficiency 

or acquired (extraciorpsular)
infections
autoimmunity
microangiopathies

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2
Q

what is the pathophysiology of extravascular hemolysisi ?

A

RBC is destroyed in the spleen or reticluendothelila tissue

= autoimmune hemolytic anemia nd heridtory spherocytosis

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3
Q

what is the pathophysiology of intravascular hemolysisi ?

A
degradation of abc inside the red blood cells 
DIC 
G6P defiance 
PK deficny 
transfusion incompatibilities
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