7: Problem Solving Basic Principles I & II

Question 1

There are _____ dL per 1 L

Answer 1

There are 10 dL per 1 L

Question 2

Use Vi for calculating _____ dose. Use Vd for calculating infusion doses.

Answer 2

Use Vi for calculating loading dose. Use Vd for calculating infusion doses.

Question 3

_____ loading dose = Vd x (Cpdesired - Cpinitial)

Answer 3

incremental loading dose = Vd x (Cpdesired - Cpinitial)

Question 4

From the first half life, we multiply the concentration we find via bloodwork by _____ to find the steady state concentration.

Answer 4

From the first half life, we multiply the concentration we find via bloodwork by two to find the steady state concentration.

Question 5

@ steady state, the rate of _____ = the rate of elimination.

Answer 5

@ steady state, the rate of administration = the rate of elimination.

Clearance = the rate of elimination

Question 6

t1/2 = ?

Answer 6

t1/2 = .693 x Vd/ Clearance

Question 7

Total body water = _____ L

ICF = _____ L

ECF = _____ L

• ECF contains plasma _____ L & Interstitial _____ L

Answer 7

Total body water = 40 L

ICF = 25 L

ECF = 15 L

• ECF contains plasma 3 L & Interstitial 12 L

Question 8

Normal GFR = _____ ml/min

Answer 8

Normal GFR = 120 ml/min