5: Basic Priciples V

Question 1

______ phase = distribution of drug

______ phase = elimination due to biotransformation or excretion

Answer 1

Alpha phase = distribution of drug

Beta phase = elimination due to biotransformation or excretion

Question 2

In Zero order absorption the size of the dose does ______ change the absorption

Answer 2

In Zero order absorption the size of the dose does not change the absorption

Question 3

First order absorption is a proportion per unit time. The larger the dose the ______ the concentration rises in the compartment

Answer 3

First order absorption is a proportion per unit time. The larger the dose the faster the concentration rises in the compartment

Question 4

Zero order elimination is an ______ per time.

Answer 4

Zero order elimination is an amount per time

Clearance = clearance metabolic + Clearance renal

Clearance metabolic = liver

Question 5

First order elimination is a ______ per unit time.

Answer 5

First order elimination is a proportion per unit time.

Question 6

Half life is only for ______ order processes.

Answer 6

Half life is only for first order processes.

Question 7

t1/2 = ?

Answer 7

t1/2 = .693/Ke

Ke = elimination rate constant, t1/2 = half life

Question 8

Clearance = ______

So

______ = .693 x Vd/Cl

Answer 8

Clearance = Vd x Ke

So

t1/2 = .693 x Vd/Cl

Cl = clearance & Vd = volume of distribution