10: Clinical Case Discussion – Cancer Flashcards
Trastuzumab is a monoclonal antibody against the ______ receptor.
Trastuzumab is a monoclonal antibody against the HER 2 receptor.
Capecitabine is an ______ prodrug converted to 5-Flourouracil which inhibits ______ which blocks DNA synthesis.
Capecitabine is an antimetabolite prodrug converted to 5-Flourouracil which inhibits thymidilate synthase which blocks DNA synthesis.
Gemcitabine is an ______ that inhibits ______ polymerase & ______ reductase.
Gemcitabine is an antimetabolite that inhibits DNA polymerase & ribonucleotide reductase.
Carboplatin is an ______ agent.
Carboplatin is an alkylating agent.
Vinorelbine is a ______ inhibitor.
Vinorelbine is a tubulin inhibitor.
Cyclophosphamide is an ______ agent.
Cyclophosphamide is an alkylating agent.
Doxorubicin is a ______ inhibitor.
Doxorubicin is a topoisomerase II inhibitor.
Paclitaxel & Docetaxel are ______ inhibitors.
Paclitaxel & Docetaxel are tubulin inhibitors.
Lapatinib is a tyrosine ______ inhibitor.
Lapatinib is a tyrosine kinase inhibitor.
ado-trastuzumab/ emtansine is composed of a trastuzumab ______ antibody and an emtansine ______ inhibitor.
ado-trastuzumab/ emtansine is composed of a trastuzumab monoclonal antibody and an emtansine tubulin inhibitor.
If a patient begins suffering from tingling in the fingers and toes after starting chemotherapy, what type of drug is causing it?
Tubulin inhibitors like Paclitaxel, Docetaxel, & Vinorelbine cause peripheral neuropathy.
Paclitaxel is most common tubulin inhibitor that gives peripheral neuropathy.
Capecitabine has a ______ half life so it is given morning and night ______ instead of IV for 1 - 2 weeks in a row.
Capecitabine has a short half life so it is given morning and night orally instead of IV for 1 - 2 weeks in a row.
Dypsnea in chemotherapy patients can be due to many causes like: ______ (low O2 content), coughing, fever, mucous production, immuno ______, ______ can cause cough, anxiety induced.
Dypsnea in chemotherapy patients can be due to many causes like: anemia (low O2 content), coughing, fever, mucous production, immunosupression, drugs can cause cough, anxiety induced.
Some causes for diarrhea in chemotherapy patients include ______ (inflammation if GI mucous membranes) & the side effects of ______.
Some causes for diarrhea in chemotherapy patients include mucocitis (inflammation if GI mucous membranes) & the side effects of drugs.
After starting chemotherapy, in order to sort out what symptoms are due to drug toxicity or not we would give the patient a trial time ______ the drug or give a ______ dose. Most importantly, we would take a good history.
After starting chemotherapy, in order to sort out what symptoms are due to drug toxicity or not we would give the patient a trial time without the drug or give a smaller dose. Most importantly, we would take a good history.
