7. Disease causes, determinants, transmission Flashcards
epidemiological triad
agent, host, environment
3 factors that influence disease potential
agent, host, and environment
agent factors
infectivity
pathogenicity
virulence
immunogenicity
antigenic stability
survival
infectivity
a measure of the ability of a disease agent to establish itself in the host
referred to qualitatively low medium high
pathogenicity
an epidemiological term used to describe the ability of particular disease agents of known virulence to produce disease in a range of hosts under a range of environmental conditions
virulence
a measure of severity of a disease caused by a specified agent
host factors
species
breed
sex
age
confirmation
genotype
nutrition status
physiologic status
pathologic status
sex factors of host example
hemophilia A = most common inherited bleeding disorder in dogs
females carry the gene
age factors of host example
arthritis in cats
environment factors
weather
housing
geography
management practises
noise
water
air
food
chemicals
Kochs postulates for infection diseases
- the agent should be present infall cases of the disease
- it can be isolated and grown in pure culture
- it should be capable of producing the disease when into healthy animals
- the same organism should be recovered from the diseased animal
limitation of kochs postulates
do not apply for inapparent infections or carrier states
some organisms are tough to grow in pure culture
rarely apply to viral infections/diseases
do not apply to multifactorial etiologies
modes of transmission
direct and indirect contact
direct transmission contact
direct contact transmission is the physical contact between an infected individual and a susceptible individual and the physical transfer of microorganisms
touching
airborne diseases
caused by pathogens and transmitted through air
droplet contact transmission
considered direct transmission which is primarily respiratory
indirect transmission
referred to situation where a susceptible person is infected from contact with a contaminated surface or material
indirect transmission
referred to situation where a susceptible person is infected from contact with a contaminated surface or material
fomite
any object or substance capable of carrying infectious organisms such as germs or parasites
food borne indirect transmission
a disease caused by consuming contaminated food and drink
vector borne indirect transmission
transmission via insect or animal vectors
horizontal and vertical transmission
horizontal = same species
vertical = to offspring
zoonosis
is any disease or infection that is naturally transmissible between vertebrate animals and humans
zoonotic disease
is a disease that can be passed between animals and human