7. ANS III Flashcards
Describe the divisions of adrenoceptors.
Divided into Alpha and Beta each with multiple isoforms.
a1, a2
b1, b2, b3
Describe what isoform a1 of the adrenoceptor controls.
The feedback loop that activates it.
Describe what isoform a2 of the adrenoceptor controls.
The feedback loop that inhibits it.
Describe where isoform a1 of the adrenoceptors are predominantly found.
Postsynaptic synapse.
Describe where isoform a2 of the adrenoceptors are predominantly found.
Presynaptic synapse.
Name the isoform of adrenoceptor that Phenylephrine effects.
a1 more that a2.
Name the isoform of adrenoceptor that Methoxide effects.
a1
Name the isoform of adrenoceptor that Clonidine effects.
a2
Describe Beta adrenoceptors.
Has two isoforms b1 and b2 both are G-protein coupled receptors.
Describe the effect of activation of isoform b1 adrenoceptor.
Causes cardiac acceleration, lipolysis, decreased gut mobility and secretion.
Describe the effect of activation of isoform b2 adrenoceptor.
Bronchodilation, vasodilation of blood vessels to skeletal muscles and glycogen breakdown.
Name the substrates of Acetylcholine.
Choline and AcetyleCoA.
Describe the uptake of acetylcholine.
Uptake into the presynaptic synapse by an active transport process.
Name the drug that inhibits acetylcholine uptake.
Vesamicol.
Describe what causes acetylcholine release.
Calcium entry into the presynaptic cleft.
