17. Molecular Pharmacology IIII

Question 1

Describe the activation mechanism of a Steroid receptor

Answer 1

Steroid receptors are inactive until a steroid ligand binds to them.
This binding displaces heat shock proteins (HSPs), enabling the receptor to dimerize.
The dimerized receptor becomes active and initiates gene transcription.

Question 2

Describe the 5 domains of a steroid receptor

Answer 2

A/B (Transactivation domain): Regulates transcriptional activity.
C (DNA-binding domain): Binds to specific DNA sequences.
D (Hinge region): Provides structural flexibility and allows for nuclear localization.
E (Ligand-binding domain): Binds the steroid and facilitates dimerization.
F (Variable domain): Function varies between receptor types.

Question 3

Describe Pharmacogenomics

Answer 3

-how genetic determinants and variability effect the way in which drugs works, control for this could reduce side effects.

-effects both pharmacokinetics and pharmacodynamics.

-Means some people may be effected differently by the same prescription depending on their genetics.