7 Addiction Flashcards
what are the three stages of addiction cycle
- binge/intoxication
- withdrawl/negative affect
- preoccupation/anticipation
consumption of drugs of abuse result in ___ experience = ___ which defines ___
hedonic (pleasure); REWARD; binge/intoxication
binging/intoxication involves what part of the brain?
basal ganglia (nucleus accumbens)
what is the experience of negative emotional state in absence of substance
withdrawl/negative affect
what portion of brain involves withdrawal/negative effect
amygdala
what occurs when one seeks substance again following period of abstinence?
preoccupation/anticipation
want-crave = ___
desire (in preoccupation/anticipation)
what part of brain involves preoccupation/anticipation
prefrontal cortex (PFC)
where are dopaminergic cell bodies located
in ventral tegmental area (VTA)
where do dopaminergic cell bodies project to?
nucleus accumbens (NAc)
what is the central role of dopaminergic cell bodies
processing reward stimuli
what bridges gap between neurons in VTA and NAc
neurotransmitter idk the specific one
what facilitates the experience of pleausre (LIKE)
dopamine
what facilitate motivation, craving and drive-neural energy to purssue goals/things
dopamine
what is involved in movement and reward-move to attain reward
DA neurotransmittter
how does one achieve the “high” experience
fast DA increasess the NAc triggered by drugs of abuse, which stable increases do not
stimulant drugs trigger ___ increases in dopamine over a ___ period of time were associated with ___
large increases; short period of time; reward
___ for drug reward effects is suggested contribution to high
rate dependency
___ or ___ administration contributes to “high”
method or route
what drug binds to and BLOCKS dopamine transporter (DAT) on presynaptic terminal
cocaine
what drug results in significantly INCREASED levels of DA within synaptic cleft
cocaine
what drug ENTERS presysnaptic terminus thru dopamine transporter (DAT)
amphetamine
what drug results in blocking reuptake of DA and facilitatess efflux of DA into the synaptic cleft
amphetamine
