7 Addiction

Question 1

what are the three stages of addiction cycle

Answer 1

1. binge/intoxication
2. withdrawl/negative affect
3. preoccupation/anticipation

Question 2

consumption of drugs of abuse result in ___ experience = ___ which defines ___

Answer 2

hedonic (pleasure); REWARD; binge/intoxication

Question 3

binging/intoxication involves what part of the brain?

Answer 3

basal ganglia (nucleus accumbens)

Question 4

what is the experience of negative emotional state in absence of substance

Answer 4

withdrawl/negative affect

Question 5

what portion of brain involves withdrawal/negative effect

Answer 5

amygdala

Question 6

what occurs when one seeks substance again following period of abstinence?

Answer 6

preoccupation/anticipation

Question 7

want-crave = ___

Answer 7

desire (in preoccupation/anticipation)

Question 8

what part of brain involves preoccupation/anticipation

Answer 8

prefrontal cortex (PFC)

Question 9

where are dopaminergic cell bodies located

Answer 9

in ventral tegmental area (VTA)

Question 10

where do dopaminergic cell bodies project to?

Answer 10

nucleus accumbens (NAc)

Question 11

what is the central role of dopaminergic cell bodies

Answer 11

processing reward stimuli

Question 12

what bridges gap between neurons in VTA and NAc

Answer 12

neurotransmitter idk the specific one

Question 13

what facilitates the experience of pleausre (LIKE)

Answer 13

dopamine

Question 14

what facilitate motivation, craving and drive-neural energy to purssue goals/things

Answer 14

dopamine

Question 15

what is involved in movement and reward-move to attain reward

Answer 15

DA neurotransmittter

Question 16

how does one achieve the “high” experience

Answer 16

fast DA increasess the NAc triggered by drugs of abuse, which stable increases do not

Question 17

stimulant drugs trigger ___ increases in dopamine over a ___ period of time were associated with ___

Answer 17

large increases; short period of time; reward

Question 18

___ for drug reward effects is suggested contribution to high

Answer 18

rate dependency

Question 19

___ or ___ administration contributes to “high”

Answer 19

method or route

Question 20

what drug binds to and BLOCKS dopamine transporter (DAT) on presynaptic terminal

Answer 20

cocaine

Question 21

what drug results in significantly INCREASED levels of DA within synaptic cleft

Answer 21

cocaine

Question 22

what drug ENTERS presysnaptic terminus thru dopamine transporter (DAT)

Answer 22

amphetamine

Question 23

what drug results in blocking reuptake of DA and facilitatess efflux of DA into the synaptic cleft

Answer 23

amphetamine