6.4 Organic Synthesis Flashcards

1
Q

How can nitriles be formed from haloalkanes ?

A

Reacting haloalkanes with NaCN or KCN in ethanol. This increased the length of the carbon chain. Occurs during nucleophilic substitution.

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2
Q

How are nitriles formed from aldehydes and ketones?

A

They react with HCN during nucleophilic addition. NaCN and sulphuric acid is used.

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3
Q

How are nitriles reduced ?

A

They can be reduced ti Maines by reacting hydrogen with a nickel catalyst.

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4
Q

How are nitriles hydrolysed ?

A

Undergo hydrolysis to form carboxylic acids by heating with dilute acid, such as HCl (aq).

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5
Q

What is alkylation ?

A

Reaction that transfers an alkyl group from a haloalkane to a benzene ring. Takes place in the presence of AlCl3.

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6
Q

What is acylation ?

A

When benzene reacts with an acyl chloride in the presence of AlCl3 catalyst, forming a ketone.

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7
Q

Alkene to haloalkane ?

A

Hydrogen halide

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8
Q

Alkene to alcohol ?

A

Hydration of steam and phosphoric acid catalyst.

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9
Q

Alcohol to alkene ?

A

Dehydration with sulfuric acid.

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10
Q

Alcohol to ester ?

A

Carboxylic acid and sulfuric acid under esterification.

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11
Q

Alcohol to haloalkane ?

A

NaX and sulphuric acid.

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12
Q

Haloalkane to primary alcohol ?

A

NaOH.

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13
Q

Alcohol to aldehyde ?

A

Acidified potassium dichromate and sulphuric acid under distillation.

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14
Q

Aldehyde to primary alcohol ?

A

NaBH4 and water under reduction.

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15
Q

Haloalkane to amine ?

A

NH3 and ethanol.

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16
Q

Haloalkane to nitrile ?

17
Q

Nitrile to amine ?

A

Hydrogen and Nickel catalyst during reduction.

18
Q

Aldehyde to hydroxynitrile ?

A

NaCN acidified under nucleophilic addition.

19
Q

Aldehyde/ alcohol to carboxylic acid ?

A

Acidified potassium dichromate under reflux.

20
Q

Nitrile to carboxylic acid ?

A

Water and HCl under hydrolysis.

21
Q

Carboxylic acid to ester ?

A

Esterification with an alcohol and sulphuric acid.

22
Q

Ester to carboxylic acid ?

A

Dilute acid hydrolysis.

23
Q

Carboxylic acid to acyl chloride ?

24
Q

Acyl chloride to carboxylic acid ?

25
Q

Ester to sodium salt ?

A

NaOH and alkaline hydrolysis.

26
Q

Acyl chloride to primary amide ?

27
Q

Acyl chloride to secondary amine ?

A

Primary amine.

28
Q

Acyl chloride to ester ?

A

Add an alcohol.