6.2 Anaemia Practice Questions Flashcards

1
Q

What is the term for abnormal sensations like pins and needles

A

Parasthesia

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2
Q

What is the most likely diagnosis megaloblastic red blood cells, low platelets (thrombocytopenia) neutropenia

A

Megaloblastic anaemia

Iron deficiency gives you microcytic anaemia
Leukaemia gives you high white cell count
Diabetes gives you peripheral neuropathy but not macrocytic?

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3
Q

What blood tests would you use to diagnoses megaloblastic anaemia?

A

Serum B12 and folate levels

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4
Q

What is the commonest cause of megaloblastic anaemia?

A

Pernicious anaemia

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5
Q

How do you diagnose pernicious anaemia?

A

Anti-intrinsic factor antibodies.

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6
Q

When are antinuclear antibodies positive?

A

Lupus

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7
Q

When are antiemdomysial antibodies positive

A

Coeliac disease

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8
Q

How do you treat pernicious anaemia?

A

IM B12

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9
Q

What happens if yiu give someone with B12 a blood transfusion?

A

Arrhythmias,

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10
Q

Why do you get a low platelet count in B12 deficiency?

A

B12 is needed for DNA repair and production of cells.

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11
Q

What is meant by pancygopenia?

A

All blood cells are low

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12
Q

What other macrocytic aneamia causes pancytopenia

A

Myelodysplasia

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13
Q

Young woman with hypochromic microcytic anaemia has low heamoglobin. What first line investaigation would you do?

A

Ferritin

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14
Q

What else would you ask a 22 year old female medical student?

A

Diet
Mennorrhagia
Pregnant
GI symptoms

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15
Q

How would you treat someone with iron deficiency anaemia?

A

Oral iron

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16
Q

When would you refer someone to GI with iron deficiency anaemia?

A

Elderly
No obvious signs of blood loss
Men
Smokers

17
Q

34 year old man with normocytic, normochromic anaemia. Blood film shows spherocytes. What other investigations would you order.

A

Reticulocyte count- shows if bone marrow is compromised
Bilirubin LDH- spherocytes suggest heamolysis
Serum haptoglobin- mops up preheamoglobin, expect to be low
DAGT (coombs test)- why someone is heamolysing