6. synaptic transmission

Question 1

synaptic transmission

Answer 1

transformation of info from neurone to target

info transferred electric-> chemical

Question 2

connections between neurones

Answer 2

axo-dendritic
axo-axonic
axo-somatic synapse (axon and body of neurone)

Question 3

Bouton

Answer 3

specialised area with vesicles with one or several nts

Question 4

Neurotransmitters

Answer 4

peptides
amino acids
catecholamines: NA, dopamine

Question 5

ionotropic

Answer 5

ionic change

1. receptor-protein: specific and sensitive to NT
2. receptor-ligand gated ion channel: fast synaptic

Question 6

Metabotropic receptors

Answer 6

ion gated channel receptors, binding is not associated with receptor but through signal transduction mechanism

Question 7

Excitatory Post Synaptic Potential

Answer 7

progressive depolarisation of membrane potential

once threshold reached-> AP

Question 8

types of summation in EPSP

Answer 8

temporal- summate over time

spatial- summate over space

Question 9

Fast excitatory synapses

Answer 9

1. Ionotropic: ligand- gated cation selective channels, mainly sodium influx
2. gated by NT molecule- centrally: glutamate, glutaminergic, peripherally: Ach cholinergic
3. EPSP: brings Vm near threshold, increase AP chance, increase excitability and summate multiple EPSPs for one AP out

Question 10

Fast inhibitory synapses

Answer 10

IPSP inhibitory post synaptic potential
inhibitors NT follows excitatory event, prevents AP fired or stop if getting to threshold

1. ionotropic: ligand gated Cl- or K+, hyperpolarise membrane
2. inhibitory post synaptic potential: Vm further from threshold, decrease chance of AP, summation inhibits AP firing decreased excitability
3. inhibitory NT are amino acid molecules
   spinal: glycine
   central GABA