6. MRI Spectroscopy

Question 1

Product of brain destruction -
present in necrotic brain tissue (necrosis
marker).

Necrotic Tissue (spilling of membrane lipids).

Elevated with high grade tumors, brain infarcts, and brain abscess.

Answer 1

Lipid

Question 2

Product of anaerobic metabolism.

Absent in normal condition

Brain tumor has outgrown
its blood supply - is forced into anaerobic
pathways for metabolism.

Also elevated with cerebral abscess.

Answer 2

Lactate

Question 3

Neuronal marker (Neuron viability)

Glial tumors have NAA
The higher the glial tumor grade = the lower the NAA

Answer 3

N-acetylaspartate

Question 4

Found in meningiomas

Amino acid

Answer 4

Alanine

Question 5

Neurotransmitter

Hepatic Encelopathy

Answer 5

Glutamine

Question 6

Energy metabolism

Decreased in tumor necrosise

Answer 6

Creatine

Question 7

Cell membrane turnover

Answer 7

Cholline

Question 8

Cell volume regulator and byproduct of glucose metabolism

Elevated:
Low grade gliomas
Alzheimers
PML

reduced:
High grade gliomas
Hepatic encephalopathy

Answer 8

Myoinositol

Question 9

Demyelinating vs Dysmyelinating

Answer 9