6. Chronic Kidney Disease Flashcards

1
Q

What is Chronic Kidney Disease?

A

Any Long-term reduction in Kidney Function

- eGFR < 60 for 3+ months

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2
Q

How many adults have CKD in the UK?

A

10% of Adults

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3
Q

What are the most common causes of CKD in London?

A
  1. Diabetes
  2. Glomerulonephritis
  3. Hypertension
  4. Polycystic Kidney Disease
  5. Pyelonephritis
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4
Q

How do we measure GFR?

A

24 Hour Creatinine Clearance (Pregnancy)

Isotopic Methods (Radioisotopes)

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5
Q

What is the best way to calculate GFR?

A

eGFR

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6
Q

How many stages of CKD are there?

A

5

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7
Q

What can you see in Stage 1 of CKD?

A

Any kidney issue but eGFR over 90

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8
Q

What can you see in Stage 2 of CKD?

A

Any kidney issue but eGFR between 60 and 90

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9
Q

What can you see in Stage 3 of CKD?

A

eGFR between 30 and 60

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10
Q

What can you see in Stage 4 of CKD?

A

eGFR between 15 and 30

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11
Q

What can you see in Stage 5 of CKD?

A

eGFR less than 15

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12
Q

Give 6 roles of the Kidney

A
  1. Removes Fluid/Sodium
  2. Controls serum pH
  3. Controls serum K
  4. Regulates BP
  5. Regulates Hb via EPO production
  6. Controls Bone and Mineral Metabolism
    - Excretion of Ca/PO and through Vitamin D
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13
Q

What happens in CKD?

A
  1. Fluid Overload/Oedema
  2. Metabolic Acidosis
  3. Hyperkalemia
  4. Hypertension
  5. Anaemia
  6. Hyperphosphatemia, Hyperparathyroidism, Hypocalcemia
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14
Q

What is the main priority in treating CKD?

A

Blood Pressure

- It tends to rise in CKD and High BP can make it get worse faster

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15
Q

What is the SECOND priority in treating CKD?

A

Reduce Proteinuria

  • Lowering BP improves proteinuria
  • ACEI also reduce proteinuria directly as do ARBs
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16
Q

What is the best supportive treatment for CKD?

A
  1. Treat Anaemia with EPO
  2. Treat Flulid Overload with Salts + Diuretics and Salt restriction
  3. Give Vitamin D or Phosphate Binder
  4. Maybe give Bicarbonate
  5. Patient dietary manipulation/restriction
17
Q

What is important in a Renal Diet?

A
  1. If the GFR is low, kidneys will struggle to remove:
    - Na, K, PO4
    - Do not eat more