6 - Body Volume Disturbances Flashcards

1
Q

effects of ATII and aldosterone on kidneys

A

ATII: stim Na/H exchange in PT
aldosterone: stim reabs of Na / excretion of K in DT and CD, also stim H ATPase in late DT and CD

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2
Q

mechanism for diuretic effect of xanthines (caffeine, theophylline)

A

inc RBF

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3
Q

how do diuretics get where they need to be?

A

secreted into tubule lumen in PT > can get to active sites on luminal side of tubules throughout nephron

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4
Q

main competitive inhibitor to diuretics

A

uric acid

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5
Q

target of loop diuretics

A

Na/K/2Cl cotransporter in ascending limb of LoH

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6
Q

where do thiazide diuretics act?

A

NaCl transporter in DCT

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7
Q

lab findings in hypovolemic pt

A

elevated BUN/CR ratio
dec urine Na
dec FeNa
hemoconcentration

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8
Q

starling law

A

determines volume transfer in capillaries

permeability * SA (dP-dOncoticP)

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9
Q

causes of edema / volume overload

A
inc venous pressure
hypoalbuminemia
inc cap permeability (burns, ARDS, malnutrition, idiopathic)
lymphatic obstruction
renal Na retention
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