6 Flashcards
Trazodone is a substrate of which CYP
CYP 3A4
are carbamazepine and depakote approved for bipolar depression in addition to mania?
no just acute mania
Somnambulism (sleep walking) and night terrors happens in which stage of sleep?
Stage IV (slow wave)
obesity rates higher in men or women?
women
conduction aphasia symptoms
repetition impaired
but relatively normal spontaneous speech
conduction aphasia lesion site
arcuate fasciculus - superior temporal or inferior parietal region
where is gabapentin excreted?
renally - no hepatic metabolism
which nerve innervates thumb, forefinger, and middle finger
median nerve
can carpal tunnel create pain up the arm to the shoulder?
yes - referred pain
most common anxiety disorder
specific phobia
clinical triad for NF-1
cafe au lait spots
neurofibromas
Lisch nodules
Does NF-1 or NF-2 lead to behavioral or cognitive impairments?
NF-1
inheritance pattern for NF-1 and NF-2
automosomal dominant
variable episodes of abdominal pain + psych symptoms with +fam hx
acute intermittent porphyria
most likely side effect of ipecac
cardiomyopathy, inc. QTc, valve insufficiency
Binswanger’s disease
AKA subcortical arterioscleotic encephalopathy
vascular dementia + gait d/o + pseudobulbar
which cognitive test helpful at diagnosing right hemispheric disease?
judgement of line orientation test (match lines of same slope)
which neuro dz is this - spontaneous crying or laughter, lability
psuedobulbar palsy
which neuro dz is this - worries or surprised appearance with opthalmoplegia, rigidity, dementia
progressive supranuclear palsy
treatment for cervical dystonia or blepharospasm
botox
rolandic epilepsy
benign childhood epilepsy - stops in adolescence, doesnt require treatment
somatosensory distubance of mouth, preserve consciousness
mucus in stool but no blood is with what disorder
IBS
inclusion body myositis versus polymyositis - which one affects more proximal versus distal muscles?
inclusion body - more distal muscles
polymyositis - more proximal muscles
tuberoinfundibular pathway goes from what to what
hypothalamus to pituitary
nigrostriatal pathyway goes from what to what
substantia nigra to basal ganglia
mesolimbic pathway goes from what to what
ventral tegmental area to nucleus accumbens
most common mitochondrial disorder
mitochondrial encephalopathy lactic acidosis and stroke like episodes (MELAS)
botox MOA
blocks acetylcholine release from presynaptic vesicles
exclusions of tpa
major surgery in last 2 weeks
signs of brain bleed
BP>185/110
painless visual loss of one eye + white matter hyperintensities + vascular risk factors
anterior ischemic optic neuropathy (AION)
can alcohol, sedatives, and inhalants cause nystagmus?
yes
criteria for brain death
- apnea test - no breathing
- absence of brain stem reflexes (ie. gagging, corneal)
- isoelectric EEG
- absence of cerebral blood flow
- coma
- no reversible causes
brisk deep tendon reflexes suggestive of upper or lower motor neuron dz?
upper
older person gets focal seizure. from what most likely?
GBM