6 Flashcards

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1
Q

Trazodone is a substrate of which CYP

A

CYP 3A4

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2
Q

are carbamazepine and depakote approved for bipolar depression in addition to mania?

A

no just acute mania

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3
Q

Somnambulism (sleep walking) and night terrors happens in which stage of sleep?

A

Stage IV (slow wave)

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4
Q

obesity rates higher in men or women?

A

women

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5
Q

conduction aphasia symptoms

A

repetition impaired
but relatively normal spontaneous speech

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6
Q

conduction aphasia lesion site

A

arcuate fasciculus - superior temporal or inferior parietal region

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7
Q

where is gabapentin excreted?

A

renally - no hepatic metabolism

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8
Q

which nerve innervates thumb, forefinger, and middle finger

A

median nerve

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9
Q

can carpal tunnel create pain up the arm to the shoulder?

A

yes - referred pain

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10
Q

most common anxiety disorder

A

specific phobia

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11
Q

clinical triad for NF-1

A

cafe au lait spots
neurofibromas
Lisch nodules

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12
Q

Does NF-1 or NF-2 lead to behavioral or cognitive impairments?

A

NF-1

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13
Q

inheritance pattern for NF-1 and NF-2

A

automosomal dominant

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14
Q

variable episodes of abdominal pain + psych symptoms with +fam hx

A

acute intermittent porphyria

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15
Q

most likely side effect of ipecac

A

cardiomyopathy, inc. QTc, valve insufficiency

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16
Q

Binswanger’s disease

A

AKA subcortical arterioscleotic encephalopathy

vascular dementia + gait d/o + pseudobulbar

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17
Q

which cognitive test helpful at diagnosing right hemispheric disease?

A

judgement of line orientation test (match lines of same slope)

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18
Q

which neuro dz is this - spontaneous crying or laughter, lability

A

psuedobulbar palsy

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19
Q

which neuro dz is this - worries or surprised appearance with opthalmoplegia, rigidity, dementia

A

progressive supranuclear palsy

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20
Q

treatment for cervical dystonia or blepharospasm

A

botox

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21
Q

rolandic epilepsy

A

benign childhood epilepsy - stops in adolescence, doesnt require treatment

somatosensory distubance of mouth, preserve consciousness

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22
Q

mucus in stool but no blood is with what disorder

A

IBS

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23
Q

inclusion body myositis versus polymyositis - which one affects more proximal versus distal muscles?

A

inclusion body - more distal muscles

polymyositis - more proximal muscles

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24
Q

tuberoinfundibular pathway goes from what to what

A

hypothalamus to pituitary

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25
Q

nigrostriatal pathyway goes from what to what

A

substantia nigra to basal ganglia

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26
Q

mesolimbic pathway goes from what to what

A

ventral tegmental area to nucleus accumbens

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27
Q

most common mitochondrial disorder

A

mitochondrial encephalopathy lactic acidosis and stroke like episodes (MELAS)

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28
Q

botox MOA

A

blocks acetylcholine release from presynaptic vesicles

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29
Q

exclusions of tpa

A

major surgery in last 2 weeks
signs of brain bleed
BP>185/110

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30
Q

painless visual loss of one eye + white matter hyperintensities + vascular risk factors

A

anterior ischemic optic neuropathy (AION)

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31
Q

can alcohol, sedatives, and inhalants cause nystagmus?

A

yes

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32
Q

criteria for brain death

A
  • apnea test - no breathing
  • absence of brain stem reflexes (ie. gagging, corneal)
  • isoelectric EEG
  • absence of cerebral blood flow
  • coma
  • no reversible causes
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33
Q

brisk deep tendon reflexes suggestive of upper or lower motor neuron dz?

A

upper

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34
Q

older person gets focal seizure. from what most likely?

A

GBM

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35
Q

which med can help with chorea in Huntington’s?

A

haldol

36
Q

triad of bacterial meningitis

A

fever, neck stiffness, headache

37
Q

2 most common bacteria to cause meningitis

A

Strep pneumo, Neisseria meningitidus

38
Q

most common pathogens for neonatal meningitis

A

Group B strep
E coli
Listeria

39
Q

What does CSF look like for GBS?

A

elevated protein
normal WBCs

40
Q

cause of olfactory aura caused by seizures from what brain area

A

medial temporal lobe

41
Q

cause of gustatory aura caused by seizures from what brain area

A

insula

42
Q

lorazepam, oxazepam, temazepam metabolized by what

A

hepatic glucuronidation (versus oxidation)

43
Q

CBC monitoring frequency of carbamazepine for agranulocytosis or aplastic anemia

A

every 3 months the first year, then can decrease frequency

44
Q

is carbamazepine’s side effects of agranulocytosis or aplastic anemia, steven johnson’s syndrome, hepatic failure, pancreatitis dose dependent?

A

no

45
Q

can you take both carbamazepine and clozapine?

A

no! risk of agranulocytosis

46
Q

most common side effects of donepezil

A

GI - nausea, abdominal cramping

47
Q

clostridium tetani causes spasms and rigidty by

A

inhibiting release of GABA and glycine (inhibitory NTs) in brain stem and spinal cord –> contractions

48
Q

which stage of sleep has sleep spindles and K complexes?

A

N2

49
Q

which stage of sleep has slowing of alpha activity?

A

N1

50
Q

which stage of sleep has slow wave delta?

A

N3

51
Q

percent of REM in total sleep in neonate versus healthy adult

A

neonate - 50%
N3 - 25%

52
Q

medication for hypertensive crisis from MAOIs and cocaine induced hypertension

A

phentolamine (alpha 1 blockade)

53
Q

biggest risk factor for childhood abuse/neglect

A

low SES - financial stress

54
Q

dissociative fugue

A

lasts min-months of sudden unexpected travel away from home with inability to recall one’s past/identity (typically triggered by trauma)

unaware

55
Q

which mental disorder is predominantly women (10:1)

A

eating disorders

56
Q

encopresis

A

repeated passage of feces into inappropriate places for >3 months

linked to sexual trauma

57
Q

pathological gamblers have what neurochemical abnormalities?

A

low plasma MHPG concentrations

low platelet MAO concentrations –> serotonergic dysfunction –> impulse issues

58
Q

for conduct disorder, symptoms have to be present before age

A

13

59
Q

which analyst created concepts of archetypes, collective unconscious, introverts vs extroverts

A

Carl Jung

60
Q

What is Eric Fromm known for?

A

creating five personality types

61
Q

What concept is Kurt Goldstein known for?

A

Self-actualization

62
Q

who proposed theories on an infant’s experience of pleasure and its effect on infant-mother relationship

A

Edith Jacobson

63
Q

benzos in pregnancy are which category

A

D

64
Q

what is the most common reason for psychiatric malpractice suits?

A

suicide

65
Q

respondeat superior in legalese

A

person occupying a high position in hierarchy is responsible for those in lower positions

66
Q

kappa is studying what

A

number for binary data that tell us if something is reliable

often measures degree of agreement between raters in a study

67
Q

does libido decrease in women during pregnancy?

A

no - for many, it increases!

68
Q

name of cognitive test where patient sees geometric figures for 10 sec and then asked to draw from memory

A

Benton visual retention test

69
Q

anticipation defense mechanism

A

planning for future inner discomfort (mature)

70
Q

which bipolar med associated with hyperparathyroidism

A

lithium

71
Q

which med associated with eosinophilic colitis

A

clozapine

72
Q

who came up with object relations theory

A

Melanie Klein

73
Q

who used the term “epigenetic view of development?”

A

Erik Erikson

74
Q

how long of worrying about future panic attack to meet criteria for panic disorder?

A

1 month

75
Q

which recreational drug can cause severe hyperthermic syndrome that can progress to DIC, rhabdo, liver/kidney failure, death?

A

MDMA

76
Q

for social anxiety, is combining CBT and SSRIs more effective than one alone?

A

no guess not

77
Q

can nurses extend seclusion time if they feel patient is still agitated

A

no - only physician

78
Q

Methadone is metabolized by CYP

A

3A4

79
Q

what’s biggest risk factor that would lead to IP over OP detox

A

history of DTs

80
Q

cyclothymic disorder criteria

A

hypomanic episodes + depressive symptoms but dont meet criteria for major depression

2 years

81
Q

if someone has hypomanic episodes and no depressive symptoms they meet criteria for

A

other specific bipolar and related disorder

82
Q

what is the correct action when patient is on clozapine and ANC is 500-999

A

stop clozapine
tried again when clozapine improves
monitor ANC daily until it’s over 1000

83
Q

what is the correct action when patient is on clozapine and ANC is 1000-1499

A

switch to 3x/week monitoring until it’s back above 1500

84
Q

what is the correct action when patient is on clozapine and ANC is <500

A

stop clozapine
only rechallenged after heme consult

85
Q

psychological side effects of interferon

A

depression, SI, cognitive inefficiency