5.Homeosis and atavism Flashcards
Homeosis
Transformation of one body segment into another due to changes in homeotic gene function.
Atavism
Recapitulation/reappereance
of ancestral traits due to mutations or developmental errors
Bicoid (BCD) protein
A maternal morphogen forming an anterior gradient that will regulate gene expression to determine head development in Drosophila.
protein-morphogen_—–gradient like the SHH
Hunchback (hb) gene
A gap gene regulated by Bicoid, responsible for early segmentation and forming a boundary between head-thorax
Homeobox
A conserved 180 bp of DNA sequence in homeotic genes encoding a DNA-binding domain/homeodomain.
Homeodomain
A protein domain encoded by the homeobox, enabling transcription factors to bind specific DNA sequences.
Knock-out mouse
A genetically modified mouse with a specific gene inactivated to study the function of the gene through resulting phenotypes.
Segment identity genes
Homeotic genes that determine the specific identity of body segments, such as Antennapedia and Bithorax.
Gill arches
Embryonic structures in vertebrates that develop into pharyngeal or middle ear components, regulated by homeotic genes.
Electroporation
A method to introduce DNA into cells by applying an electric field to create temporary membrane pores.