58. The tolerance to foreign antigens. Immunosuppression - significance to medicine.

Question 1

Immunosuppressive therapy is most essential part of aloo-transplantation. Cyclosporne and tacrollmus inhibits IL-2 synthesis following Ag-receptor binding whereas rapamycin interferes with signal transduction following IL2-IL2R interaction. Thus, all these agents block T cell proliferation in response to an antigen.

Answer 1

Immunosuppressive therapy is most essential part of aloo-transplantation. Cyclosporne and tacrollmus inhibits IL-2 synthesis following Ag-receptor binding whereas rapamycin interferes with signal transduction following IL2-IL2R interaction. Thus, all these agents block T cell proliferation in response to an antigen.

Question 2

In bone marrow transplantations, the most crucial factor in donor selection is class II MHC compatibility. Identical twin is donor. T lymphocytes removed using monoclonal antibodies from poorly matched grafts. The recipient must be immunosuppressed. Malignant cells must be removed from the recipients blood.

Answer 2

In bone marrow transplantations, the most crucial factor in donor selection is class II MHC compatibility. Identical twin is donor. T lymphocytes removed using monoclonal antibodies from poorly matched grafts. The recipient must be immunosuppressed. Malignant cells must be removed from the recipients blood.

Question 3

Immunosuppression, reduces the effectivity of your immune system.

Deliberately induced immunosuppression is performed to prevent the body from rejecting an organ transplant, treating graft-versus-host disease after a bone marrow transplant - or for the treatment of auto-immune diseases like lupus erythematous, rheumatoid arthritis or Crohn’s disease - usually done using medication, but can be done by spleen removal or radiation.

Answer 3

Immunosuppression, reduces the effectivity of your immune system.

Deliberately induced immunosuppression is performed to prevent the body from rejecting an organ transplant, treating graft-versus-host disease after a bone marrow transplant - or for the treatment of auto-immune diseases like lupus erythematous, rheumatoid arthritis or Crohn’s disease - usually done using medication, but can be done by spleen removal or radiation.

Question 4

Immunocompromised - a person that’s undergoing immunosuppression, or has a weak immune system due to HIV or chemotherapy

Immunosuppressant - any agent that weakens the immune system - immunosuppressive drugs and other environmental toxins

Answer 4

Immunocompromised - a person that’s undergoing immunosuppression, or has a weak immune system due to HIV or chemotherapy

Immunosuppressant - any agent that weakens the immune system - immunosuppressive drugs and other environmental toxins

Question 5

Non-deliberate immunosuppression: can occur due to malnutrition, ageing, cancers (leukemia, lymphoma, multiple myeloma), HIV. Unwanted result - increased susceptibility to pathogens - bacteria, viruses, fungi.

Answer 5

Non-deliberate immunosuppression: can occur due to malnutrition, ageing, cancers (leukemia, lymphoma, multiple myeloma), HIV. Unwanted result - increased susceptibility to pathogens - bacteria, viruses, fungi.