56. Major Histocompatibility complex - H-2 and HLA system. Flashcards
The major histocompatibility complex is a set of cell surface molecules encoded by a large gene family which controls a major part of the immune system. The main part of the specific immune system are T and B cells, which have different functions.
The major histocompatibility complex is a set of cell surface molecules encoded by a large gene family which controls a major part of the immune system. The main part of the specific immune system are T and B cells, which have different functions.
B cells take part in the humoral immune reaction by differentiating into plasma cells, which secrete antibodies specific to the antigen.
B cells take part in the humoral immune reaction by differentiating into plasma cells, which secrete antibodies specific to the antigen.
The T cells protect the body from intracellular pathogens by cytotoxic (Tc) cells and they help in the activation of other cells of the immune system e.g. macrophages, B lymphocytes. These cells are called T helper cells (Th). In the free state, T lymphocytes are not able to recognise intact antigens. T cells only recognise antigenic peptides when they are represented on the cell membrane of an organisms own cell.
The T cells protect the body from intracellular pathogens by cytotoxic (Tc) cells and they help in the activation of other cells of the immune system e.g. macrophages, B lymphocytes. These cells are called T helper cells (Th). In the free state, T lymphocytes are not able to recognise intact antigens. T cells only recognise antigenic peptides when they are represented on the cell membrane of an organisms own cell.
The antigenic peptides are non-covalently bound to the membrane associated molecules. These molecules are proteins that are specialised to present an antigen to T cell. They are encoded by a group of highly polymorphic genes in a chromosome region called the MHC or Major histocompatibility complex. Alternate name, Human Leukocyte Antigens because these molecules were first discovered on human leukocytes.
The antigenic peptides are non-covalently bound to the membrane associated molecules. These molecules are proteins that are specialised to present an antigen to T cell. They are encoded by a group of highly polymorphic genes in a chromosome region called the MHC or Major histocompatibility complex. Alternate name, Human Leukocyte Antigens because these molecules were first discovered on human leukocytes.
The products of MHC genes are the MHC molecules are an obligatory component of the antigenic complex which is recognised by T cell receptors. The MHC region is divided into 3 subregions with genes of different classes.
The products of MHC genes are the MHC molecules are an obligatory component of the antigenic complex which is recognised by T cell receptors. The MHC region is divided into 3 subregions with genes of different classes.
Class I and class II are membrane associated glycoproteins which participate in the presentation of antigens to T lymphocytes.
Class I and class II differ in their cellular distribution, their structure, their recognition of different T cell populations and their organisation in gene complexes in the MHC region. MHC III products are not related to antigen presentation, they are structurally and functionally different to the other 2 classes.
Class I and class II are membrane associated glycoproteins which participate in the presentation of antigens to T lymphocytes.
Class I and class II differ in their cellular distribution, their structure, their recognition of different T cell populations and their organisation in gene complexes in the MHC region. MHC III products are not related to antigen presentation, they are structurally and functionally different to the other 2 classes.
MHC class I is recognised by T cytotoxic cells (CD8+) and it’s expressed by a nucleate somatic cell.
MHC class II is recognised by Th (T helper) lymphocytes (CD4+) and is expressed by cells of the immune system, mainly the professional antigen presenting cells.
MHC class I is recognised by T cytotoxic cells (CD8+) and it’s expressed by a nucleate somatic cell.
MHC class II is recognised by Th (T helper) lymphocytes (CD4+) and is expressed by cells of the immune system, mainly the professional antigen presenting cells.
