5.5 Histology of the Female Reproductive System Flashcards
Surface epithelium of ovaries
Simple cuboidal epithelium aka germinal epithelium
Responsible for whitish color of the ovary
Tunica albuginea
Tunica albuginea is composed of _______ connective tissue
Dense connective tissue
Ovarian parenchyma has two layers namely
Cortex and medulla
Part of the ovarian parenchyma that contains highly cellular CT and ovarian follicles
Cortex
Part of the ovarian parenchyma that contains loose CT and blood vessels
Medulla
Correct order of follicular growth and development phases
Primordial - unilaminar primary - multi laminar primary - secondary / antral - mature/ graafian - ovulation
In the beginning of puberty, pituitary gland releases which hormone
FSH
The primordial follicle contains chromosomes in which meiosis stage
First meiotic prophase
Follicular Stage which form simple cuboidal epithelium around the primary oocyte
Unilaminar primary follicle
Follicular stage where granulosa cells are first formed
Multilaminar primary follicle
Epithelium of multilaminar primary follicle
Stratified cuboidal
Follicular stage characterized by complete zona pellucida
Multilaminar primary follicle
ZP1-ZP4 functions to
Binding proteins on sperm surface to induce acrosomal activation
Follicular stage characterized by accumulation of follicular fluid or liquor folliculi
Antral follicle
Vascularized endocrine tissue that secretes androstenedione
Theca interna
Cells that aromatize the steroid into estradiol
Theca cells
Thecal layer with smooth muscle and fibroblasts
Theca externa
Most developed stage of follicular growth
Graafian
Part of graafian follicle that protrudes into the antrum
Corpus oophorus
Accompanies the oocyte when it leaves the ovary
Corpus radiata
Phase where in Antrum increases in size and accumulates follicular fluid rapidly
Graafian
Graafian follicle develops from a primordial follicle in over a period of ____ days
90 days
Graafian follicle has ______ granulosa layer and _____ thecal layer
Thinner granulosa layer, thick thecal layers
How many chromosomes are there in a primary oocyte?
46 or 23 pairs, diploid cell
How many chromosomes are there in a secondary oocyte?
23, haploid
Primary follicles that do not mature undergo what process
Atresia - degeneration of ovarian follicles that do not ovulate during menstrual cycle
Primary oocytes are arrested at what stage
Prophase I
Secondary oocytes are arrested at what stage
Metaphase II
Final viable product of oogenesis
Ovum (haploid)
Before birth primordial germ cells differentiate into
Oogonium
Lining ep. of fallopian tube
Simple columnar ciliated ep
Most common site of ectopic pregnancy in fallopian tubes
Ampulla
Most common site of RUPTURED ectopic pregnancy in fallopian tubes
Isthmus
Addt’l innermost longitudinal layer of muscularis of fallopian tubes
Intramural
Mucosa of fallopian tubes is most prominent in which part
Ampulla
Muscularis layer of fallopian tube is thicker in ehich part
Isthmus
Epithelial lining of mucosal layer of fallopian tube
Simple columnar ep
Cells that help transport oocyte to uterus
Ciliated cells
Produces nutritive fluid covering of epithelium
Peg cells
Function of peg cells
Produces nutritive fluid covering of epithelium
In the luteal phase, there is accumulation of
Glycogen
Corpus luteum of menstruation is programmed to secrete
Progesterone for 10-12 days
Difference bet corpus luteum in menstruation and pregnancy
Bigger size of corpus luteum of pregnancy
Makes up most of corpus luteum (85%)
Granulosa lutein cells
Granulosa lutein cells secrete _________ from androstenedione and secrete _________
Estradiol and progesterone
From theca interna
Theca lutein cells
Theca lutein cells secrete
Progesterone and androstenedione
If pregnancy does not occur, corpus luteum will degenerate to form
Corpus albicans - scar tissue from ovarian follicle
Corpus albicans is composed of
Collagen with few fibroblasts
Advanced atresia is characterized by
Glassy membrane - thickening of basement membrane bet. Theca interna and granulosa cells
Follicular atresia is most prominent at
Just after birth
Atretic follicles are replaced by
Corpus fibrosum
Termination of uterus
Cervix
Outer CT layer of uterus
Perimetrium - laregly serosa, some adventitia, continuous with ligaments
Thickest tunic of uterus
Myometrium - highly vascular : stratum vasculare - 4 woven but poorly defined layers
Layers of myometrium parallel to long axis of uterus
1st and 4th layers
Myometrium layers that have circular width with large bld v
Middle layers
Epithelial lining of endometrium layer of the uterus
Simple columnar ep with alternating secretory cells (forms uterine glands) and ciliary cells
Stroma of the Endometrium contains
Type III collagen, abundant fibroblast
Straight a.
Basal layer
Spiral a.
Functional layer
Functional layer changes depending on what hormone
Estrogen
Phase in menstrual cycle characterized by increased estrogen
Proliferative phase
Proliferative phase has uterine glands that are
Straight
Secretory phase has uterine glands that are
Highly coiled
Phase in menstrual cycle characterized by increased progesterone and glycogen
Secretory or luteal
Phase with maximum endometrium thickness
Luteal secretory phase
Menstrual phase is characterized by decrease in
Progesterone and estrogen
Endocervix lining
Mucus secreting simple columnar ep
Ep lining of exocervix
Stratified non keratinized squamous ep
Most susceptible to cancer ca, dysplacia
Transformation zone
Pinkish orange cytoplasm in cervical smear
Surface cells
Blue green cytoplasm in cervical smear
Subsurface cells
Epithelium of vagina
Stratified squamous
Vagina is covered by
Adventitia
Causes low ph in vagina
Lactic acid from glycogen
Forms the future placenta
Deciduas basalis and trophoblast
Decidua lining rest of uterus
Decidua parietalis
Decidua overlying embryo
Decidua capsularis
Stage of chorionic villus that appears 15th day after implantation
Secondary villus
Stage of chorionic villus that appears 2nd day after implantation
Primary villus
Stage of chorionic villus with proliferating cytotrophoblast and synctiotrophoblast
Primary villus
Stage of chorionic villus where there is mesenchyme tissue invasion by fetal artery
Tertiary villus
Premature placenta layer
Cytotrophoblast
Outer layer of premature placenta
Synctiotrophoblast
Mature placenta is distinguished by
Synctial knots : aggregation of synctiotrophoblasts
Embryo is surrounded by
Extraembryonic coelom
The fetus is surrounded by
Amniotic cavity
Umbilical cord is composed of
2 umbilical arteries and 1 umbilical vein
Umbilical cord consists of mainly mucous CT named
Wharton’s Jelly