2.4 Myeloid Flashcards
AKA Colony forming units
Progenitor cells
AKA hemopoietic cytokines
Colony-stimulating factors
Source of TPO
Kidney and liver
Source of EPO
Kidney and hepatocytes
ECM composition of bone marrow
Collagen tupe IProteoglycansFIbronectinLaminin
Marrows of newborns
Red bone marrow
Marrows of adults
Yellow bone marrow
Stimulates production of RBCs in the bone marrow
Hemopoietic growth factor, erythropoietin
Stage of erythrocyte maturation where hemoglobin synthesis starts but is not significant enough to change the color of the cytoplasm
Basophilic erythroblast stage
Stage in erythrocyte maturation where hemoglobin synthesis is more significant and characterized by lilac color due to presence of both pasiphilia and acidophilia
Polychromatic erythroblast stage
Earliest and first recognizable stage of the RBC maturation
Proerythroblast
Stage with checkerboard patternStart of synthesis of Hgb
Basophilic erythroblast
Stage with lilac color of rbc maturation, more condense nucleusAfter this stage, mitotic activity ceases
Polychromatophilic erythroblast
RBC stage similar to a mature erythrocyteFried egg appearanceNucleus is found at one sideAcidophillic cytoplasm
Orthochromatophilic erythroblast (normoblast)
Most immature recognizable cell in the myeloid series
Myeloblast