5.1 Antivirals

Question 1

What are the types of influenza virus?

Answer 1

A - antigenic shift/drift, animal hosts, common and severe

B - no antigenic shift

C- uncommon, less severe

Question 2

How do viruses replicate?

Answer 2

Enter Blood
Attachment - to Sialic acic or neuraminic residue
Endocytosis
Uncoating- H+ entry
RNA/DNA/Protein replication
Budding

Question 3

What are M2 ion channel blockers?

Answer 3

Block the M2 receptor on the virus
Normally allows H+ entry which uncoats it allowing RNA etc to enter the cytoplasm

Prevents REPLICATION

Question 4

Examples of M2 blockers

Answer 4

Amantadine

Rimantadine

Question 5

ADRs of M2 blockers?

Answer 5

GI symptoms
Hypotension
Confusion and Hallucination
Insomnia

Question 6

Use M2 blockers when?

Answer 6

Influenza A only

Question 7

What are Neuroamidase inhibitors?

Answer 7

Prevents neuroamidase which breaks down the residue bond when a viron buds off

Prevents BUDDING

Question 8

What are the properties of Neuroamidase inhibitors?

Answer 8

High affinity
High potency
Treats A and B

Question 9

What are some ADRs of Neuroamidase inhibitors?

Answer 9

GI
Headache
Nosebleed
Nothing tooooo serious

Question 10

Examples of N Inhibitors

Answer 10

Oseltamivir

Zanamivir

Question 11

Rarely what can happen with NIs?

Answer 11

Respiratory Depression

Bronchospasm