10.1 Anti-arrhythmics Flashcards
What do Class 1 anti-arrhythmics do?
Examples?
Block Na+ Channels
Procainamide
Lidocaine
Fleconide
What do Class 2 anti-arrhythmics do?
Examples?
Beta Adrenoceptor Antagonists
Propranalol
Osmolol
What do Class 3 anti-arrhythmics do?
Examples?
Block K+ Channels
Sotalol
Amiodarone
What do Class 4 anti-arrhythmics do?
Examples?
Block Ca2+ Channels
Verapamil
When do you use Procainamide?
When do you use Quinidine?
Acute SVT
Maintain Sinus Rhythm in AF
When do you use Lidocaine?
Ventricular Tachycardia
When do you use Propranalol?
In Sinus Arrythmias
When do you use Fleconide?
WPW
Premature Contractions
SVT
When do you use Amiodarone?
AF
Angina
When do you use Sotalol?
SVT/VT
When do you use Verapamil?
Hypertension
Angina
AF (decrease ventricular rate)
SVT
What are the ADRs of Class Ia?
Hypotension
Lupus-like symptoms
Pro-arrythmic
What are the ADRs of Class Ib?
Pro-arrhythmic
Dizziness
What are the ADRs of Class Ic?
Pro-arrhythmic
Cannot use in damaged tissues
Sedation
Nausea
What are the ADRs of Class II?
Hypotension
Bradycardia
Bronchospasm
What are the ADRs of Class III?
Amiodarone?
Pulmonary Fibrosis
Thyroid
LDLs
Hepatic Injury
What are the ADRs of Class III?
Sotalol?
Fatigue
Insomnia
Arrhythmia
What are the ADRs of Class IV?
AV Conduction problems
Hypotension
Liver Faiure
What is the effect of Class Ia?
Decrease Phase 0 slope
Decrease Phase 4 slope
Longer QT (refractory period)
What is the effect of Class Ib?
Decreases phase 3 and AP
No effect on normal tissues
Good on rapidly firing tissues
What is the effect of Class Ic?
Decreases Phase 0
Lengthens AP and automacity
Whole ECG changes
What is the effect of Class II?
Slows heart rate and lowers contraction
Lowers phase 4 slope
Decreases AV conduction
What is the effect of Class III?
Longer AP and Refraction
Increases threshold to lower automacity
Lowers AV conductance
What is the effect of Class IV?
Decrease Automacity
Decrease AV conductance
Increase refraction and slope of phase 4
