5. Polyagglutination Flashcards
What causes a repulsive electric zeta potential between cells?
Carboxyl groups of sialic acids on RBC membranes
Example of a panagglutin?
auto-anti-I
b/c all adult cells have I antigens
What type of Ig is anti-T and what type of population is it found in?
IgM
All adults
Peanut lectin = ?
Arachis hypohaea
3 types of inherited polyagglutination?
HEMPAS
Sd(a++); Cad
NOR
Why don’t cord (newborn) plasma have anti-T?
Anti-T are developed after exposure to environmental factors
How to avoid hemolysis when transfusion w/ T-activated RBCs?
Use washed cellular products (remove any plasma)
Purpose of lectins
To check for exposure of T antigens on RBCs (lectins will react with T antigens)
Soya bean lectin = ?
Glycine soja
Most common ACQUIRED polyagglutination?
T-activation
T-activation is also known as the _________ phenomenon
Thomsen-Hubener-Friedenreich phenomenon
What is a cryptantigen
AKA T antigen
Present on surface of all RBCs but masked by sialic aci
T-activation of red cells is most often seen in ________ with infections
children
Enzyme produced by microbes that remove sialic acid from RBC membranes = exposes T antigens
Neuraminidase
Alternative way RBCs can become T activated?
In vitro by bacterial contamination of specimen
Patient autocontrol would be positive
