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Transfusion Science 2 > 10. Blood and Blood Components > Flashcards

10. Blood and Blood Components Flashcards

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1
Q

Rare phenotype bank; autologous blood for patients w/ rare phenotypes

A

Frozen red cells

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2
Q

Products cannot be returned to inventory if out of fridge for greater than this length of time

A

30 mins

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3
Q

Max time for infusion is ___ hrs from the time product is removed from sotage

A

4 hrs

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4
Q

2 types of coagulation factor concentrates

A

Plasma derived factors

Recombinant factors

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5
Q

3 reasons why cryoprecipitate doesn’t need to be ABO/Rh compatible w/ patient

A
  • No ABO antibodies in cryoprecipitate
  • Amount of RBCs in cryo is relatively insignificant = unlikely to stimulate antibody production
  • There is NO plasma in cryo
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6
Q

You almost always have to use a _______for blood products

A

filter

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7
Q

Term for when you have your own blood saved for the sole purpose of it being transfused back to you

A

Autologous donation

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8
Q

Is a gammaglobulin “booster” - provides passive antibody protection after exposure to HepA, measles

A

Intramuscular immune globulin (GamaSTAN)

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9
Q

Product used in plasma exchanges for patients who have had an allergic rxn to regular plasma

A

Solvent detergent treated plasma

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10
Q

By how much can you expect HGB to change after transfusion of 1 unit of PRBCs?

A

+10 g/L

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11
Q

Which product request will require an antibody screen on the patient?

A

RBC request

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12
Q

Storage life and temperature of albumin

A

RT for 2-5 yrs

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13
Q

Cryoprecipitate shelf life if thawed

A

4 hrs @RT

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14
Q

Most common cause of HLA antibody development

A

Chemotherapy

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15
Q

This product is NOT normally used and must not be mistakenly used as regular plasma

A

Cryosupernatant plasma

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16
Q

Primary use of IVIg?

A

Immune deficiencies (hypogammaglobulinemia, lymphoma, off label use)

17
Q

This can be used to treat patients w/ hemophilia or fibrinogen defects (e.g. hemophilia A, von Willebrand disease)

A

Cryoprecipitate

18
Q

Product of preference for children; is used for patients w/ HLA antibodies

A

Pheresis platelets (single donor)

19
Q

Frozen red cells shelf life

A

10 yrs at -65degC/lower

24 hrs at 1-6 degC if deglycerolized

20
Q

Main difference with frozen red cells?

A

Water in RBCs replaced w/ glycerol before freezing

21
Q

Frozen plasma has reduced _________________ activity

A

Factor V and VIII

22
Q

Purpose of platelet titring?

A

Determine if platelet unit has high tires of anti-A and/or anti-B

QUALITATIVE not quantitative

23
Q

Fractionated products require a tubing with a ___ micron filter

A

15 micron

24
Q

Frozen plasma shelf life?

A

-18 degC or lower for 1 yr

25
Q

What percentage of albumin has the same oncotic pressure as plasma?

A

5%

26
Q

You can’t predict how much this value changes after transfusion b/c too many variables

A

INR

27
Q

How much can you expect the PLT count to change after transfusion of 1 dose of PLTs?

A

at least 15 x 10*9/L

28
Q

If frozen plasma is thaws, what is its new shelf life

A

5 days at 1-6 degC

29
Q

4 other diagnoses for women that should be a flag for possible RhIg

A
  • threatened abortion
  • missed abortion
  • ectopic pregnancy
  • vaginal bleed
30
Q

Used as part of a Homecare Program where patients can administer it to themselves

A

Subcutaneous immune globulin (SCG)

31
Q

Temperature and shelf life of PRBCs

A

1-6 C
21 days w/CPD
35 days w/CPDA-1
42 days w/CPDA-1 + SAGM

32
Q

Term for when a donation is collected with a specific recipient in mind

A

Directed donation

33
Q

HLA matched platelet can be considered a _________ donation

A

directed

34
Q

2 reasons why PLTs don’t have to be compatible with patient’s ABO

A
  • Amount of RBCs in PLT unit is relatively insignificant = unlikely to stimulate antibody production
  • Can test to ensure the PLT unit doesn’t contain high titres of anti-A/B
35
Q

Is cryoprecipitate fresh or fractionated?

A

Fresh

36
Q

How much does fibrinogen change after 1 dose of cryoprecipitate?

A

0.5 - 1.0 g/L

37
Q

Term for when product’s usage has an unknown mechanism

A

off label

38
Q

Forms that IVIg comes in

A

Lyophilized

Liquid

Transfusion Science 2 (11 decks)

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