5. Oxidation of pyruvate to acetyl~CoA. Steps, necessary cofactors, importance, Glycerol phosphate shuttle

Question 1

Steps of oxidation of pyruvate to acetyl~CoA :

Answer 1

Question 2

Necessary cofactors:

Answer 2

TPP, Lipoic acid, NADH+H+, SH-CoA, FAD

Question 3

Importance of the oxidation of pyruvate to acetyl~CoA:

Answer 3

Acetyl- CoA has an importante role in glycolysis, TCA, Respiratory chain, ATP production

Question 4

Explain what the glycerol phosphate shuttle is:

Answer 4

The glycerol-3-phosphate shuttle is a mechanism that regenerates NAD+ from NADH, a by-product of glycolysis. Its importance in transporting reducing equivalents is secondary to the malate-aspartate shuttle.

Question 5

Glycerol phosphate shuttle :

Answer 5