5 Friends (or 2) Dosages Flashcards
1
Q
Phenylephrine alternate name:
A
Neosynephrine
2
Q
Phenylephrine structure:
A
Synthetic non-catecholamine sympathomimetic
3
Q
Phenylephrine MOA:
A
- Alpha 1 stimulation (Gq)
- Vasoconstriction arterial/venous
- Stimulation of phospholipase C → hydrolyzes PIP2 to IP3 and DAG which both release intracellular Ca → vasoconstriction
4
Q
Phenylephrine Onset:
A
Immediate
5
Q
Phenylephrine duration of action:
A
5-20 min
6
Q
Phenylephrine PB:
A
90%
7
Q
Phenylephrine Metabolism:
A
Monamine Oxidase
8
Q
Phenylephrine IV bolus dose:
A
50-200 mcg
9
Q
Phenylephrine IV infusion dose:
A
20-200 mcg/min
10
Q
Phenylephrine IV / Kg infusion dose:
A
0.05-1 mcg/kg/min
11
Q
Phenylephrine side effects:
A
- Increased SVR
- Increased BP
- Increased ICP
- Increased CVP
- *Decreased CO
12
Q
Phenylephrine contraindications / cautions:
A
- Reflex Bradycardia
- Do not give if low HR
- Do not give to peds (rate dependent)
- Use with MAOIs can lead to severe hypertensive crisis
- Pheochromocytoma
13
Q
Ephedrine alternate name:
A
Corphedra
14
Q
Ephedrine Structure:
A
Synthetic non-catecholamine sympathomimetic
15
Q
Ephedrine MOA:
A
- A1, B1 & B2 stimulation (Gq/Gs) more beta than alpha
- Directly stimulates A1 & B2 receptors
- Indirectly taken up by sympathetic nerve endings & displaces noradrenaline from storage in synapse → produces indirect A1 & B1 effects
- Indirectly inhibits the intraneuronal metabolism of NE by mitochondrial MAO = more NE
