5: Cardio Flashcards

1
Q

Potassium

A

imbalance causes disruption of resting cell membrane potentials
deficiency: fatigue, weakness, postural HYPOTN, HTN

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2
Q

Magnesium

A

neutralizes anionic species (eg ADP, ATP)
cofactor in carb, lipid, protein, nucleic acid metabolism
cofactor in 2nd messenger systems for hormones, neurotransmitters
prevents coronary a. spasm
def can cause arrhythmias
IV for v fib and arrhythmia secondary to digoxin use

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3
Q

Vit D

A

may tx HTN

low levels assoc with PAD

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4
Q

Sources of Cu

A

Brazil nuts, almonds, pecans

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5
Q

Chromium

A

improves insulin sensitivity

modest decrease in serum cholesterol and increase in HDL

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6
Q

Vit C

A

antiox, anti-inflamm
atherosclerosis assoc with vit C def
support for CT

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7
Q

B5 Pantethine

A

precursor to CoA

may decrease total cholesterol

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8
Q

Choline

A

fat metabolism
lowers homocysteine
precursor to ACh
phosphatidyl choline may decrease atherosclerosis

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9
Q

Good sources of Calcium

A

Kelp, cheddar cheese, green leafy veggies

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10
Q

B3 Niacin

A
Only niacin (not nicinamide) effects serum lipids
augment statin therapy

SEs: flushing, itching, urticaria, may alter blood glucose, hyperuricemia, worsening of unstable angina, macular edema, hyperpigmented skin lesions, GI sxs, ulcers

*hepatotoxicity!

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11
Q

Calcium and physiology

A

second messenger: musc contraction, neurotransmitter release, exocrine and endocrine gland secretion, chromosome movement

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12
Q

L carnitine

A

facilitates transport of FAs into mitochondria

increase exercise tolerance, survival time in LVEF

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13
Q

Omega 3s

A

precursor to PGE3, LK B5

IND: intermittent claudication, angina, decrease CRP, decrease TGs, athrosclerosis

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14
Q

Copper

A

cofactor for lysyl oxidase involved in collagen and elastin cross linking, neuropeptide/transmitter syn, release of stored Fe, cytochrome C
support for CT

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15
Q

Zinc

A

involved in alcohol DH, bone formation, SOD, collagen remodeling
antioxidant

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16
Q

Potassium effects on CV

A

anti HTN, decreases atherosclerotic plaques

decreased incidence of stroke

17
Q

CoQ10

A

mitochondrial nutrient
antioxidant
IND: stable angina, improved endothelial fxn, increased EF (in CHF and dilated cardiomyopathy), HTN, MVP

18
Q

Vit K

A

involved in clotting

cofactor in inhibitor of vascular calcification (Matrix Gla)

19
Q

Ca effect on CV

A

can deposit in walls of arteries resulting in HTN and angina
deposition initiated by injury and inflammation
**ideal to get through the diet: dairy, bone broth*

20
Q

B6 Pyridoxine

A

cofactor for lysyl oxidase, promotes collagen and elastin cross linking
decreases homocysteine
inhibits glycosylation of LDL

21
Q

B12 Cobalamin

A
decreases homocysteine
def may be assoc w carotid plaques
22
Q

D Ribose

A

improves diastolic function in CHF

23
Q

Riboflavin

A
component of FAD and needed for ATP
def assoc with CHF
24
Q

Good sources of potassium

A

avocado
potato (with peels)
banana

25
Q

Selenium

A

cofactor in GSH peroxidases, T4 to T3, protein folding

def endemic in China (soil): Keshan cardiomyopathy

26
Q

Magnesium and stress

A

catecholamines depletes Mg from myocardium

depletion increases catecholamine release and increases cardiotoxic effects of epinephrine

27
Q

L Arginine

A

precursor to NO- vasodilator- improved endothelial function
improve exercise capacity
give with tocopherols

28
Q

Calcium nutrient interactions

A

Ca supplementation may increase Mg requirement (and vice-versa)
Can result in poor absorption of Zn and Fe
LYS can increase absorption

29
Q

B9 Folic acid

A

decreases homocysteine

improves endothelial dysfxn in those with CVD

30
Q

Vitamin E - Tocopherols alpha, beta, gamma, delta

A

antioxidant in lipids

may inhibit platelet aggregation