2: Neuro Flashcards
When is a nutrient a drug?
A nutrient facilitates normal physiologic function
A drug induces abnormal function
Nutrients to supplement in Parkinsons
L-cysteine/GSH precursors (low in PD and depleted by L-dopa)
B6 to alleviate dyskinesias
L tyrosine to manage melanin steal-related deficiency
5HTP to control N (from L-dopa)
Carbidopa
pharmaceutical which is indicated in Parkinson’s because it allows more L-dopa to cross BBB
can cause B def, GSH def, N, inhibit synthesis of serotonin
Wahls approach
developed to tx her own MS to support mitochondria
grain free, dairy free, high veg (9 servings daily)
Diseases assoc w mitochondrial dysfunction
Huntington’s disease Parkinson’s disease Alzeimer’s dementia Amyotrophic Lateral sclerosis Charcot-Marie-Tooth Primary optic atrophy migraines fibromyalgia chronic fatigue, etc
what do mitochondria do again?
Generate ATP, fatty acid oxidation, biosynthesis of amino acids and steroids, cytosolic calcium homeostasis, production and modulation of ROS, play a role in apoptosis
*Neurons are particularly vulnerable to their limited ability to regenerate and their high energy demand
Interventions to support mitochondrial function
Dysbiosis correction Refined carbohydrate restriction Therapeutic fasting Dietary antioxidant intake Supplementation Exercise
Fibromyalgia Tx
CoQ10 – 200-400 mg/day Acetyl-L-carnitine – 500 mg tid Magnesium 300-800 mg/day (to bowel tolerance) Melatonin – 5-15 mg at bedtime 5-HTP– 50-150 mg tid therapeutic fasting--very anti inflammatory! Thiamine – 600–2,000 mg/day GF diet
Diabetic neuropathy pathophys
Hyperglycemic oxidative stress Advanced glycation end product formation Mitochondrial dysfunction Added oxidative stress Neural apoptosis
Diabetic neuropathy tx
GLYCEMIC CONTROL!
Acetyl-L-carnitine – 1g tid
*Anti-nociceptive in neuropathic pain, activation of cortical inhibitory pathways
*Mitochondrial nutrient
Vitamin B12 – 1-2mg/day (ESP if taking metformin)
Migraine HA Pathophys
Mitochondrial dysfunction
Excess ROS production
CSF lactic acidosis -d/t impaired pyruvate utilization and subsequent shunting into lactate dehydrogenase pathway
Reduced mitochondrial enzymatic activity (COX, NADH dehydrogenase, Citrate synthase)
Morphologic alterations
Migraine Precipitating Factors
Food triggers (Chocolate, Cheese, Citrus fruit, Red wine, Coffee and caffeine, aspartame, MSG, nitrates)
Migraine prophylaxis
Magnesium citrate – 600-800 mg/day
Mg def assc w CSD cortical spreading depression, Vascular tone dysregulation, inflammation, Impaired ATP synthesis
Riboflavin (B2) 15-400 mg/day
Coenzyme Q10 – 200-400 mg/day
