4: Derm

Question 1

Psoriasis Pathophys

Answer 1

AI
keratinocyte hyperproliferation, increased angiogenesis, antimicrobial peptides
high genetic susceptibility

(high co-prevalence of Metabolic Syn)

Question 2

Psoriasis Supplementation

Answer 2

Vit A, preformed- promotes Treg/suppresses Th17
Vit D
Alpha lipoic acid
EPA + DHA Fatty acids
Zinc picolinate/citrate

Question 3

Psoriasis Deficiencies

Answer 3

Vit A, Zn
GSH
Vit D

Question 4

Rosacea Nutritional Tx

Answer 4

Elimination Diet
Anti-inflammatory Diet
Zinc
Lipase supplementation

Question 5

Rosacea Triggers

Answer 5

alcohol, hot liquids, spicy foods

Question 6

Furunculosis Risk Factors

Answer 6

deficits in hygiene, obesity, DM, other skin dz, prior abx tx, immunosuppressive tx, less personal sleeping space

Question 7

Atopic Derm Tx

Answer 7

Within three minutes: SLATHER in salve (Lipid replacement- ceramide, FFA, cholesterol)

Question 8

Acne Vulgaris supplements

Answer 8

Curcumin
Zinc
ECGC
Low-mod dose vitamin A

Question 9

Atopic Derm Pathophys

Answer 9

Filaggrin deficiency
FLG: essential protein in epidermis; common mutation in AD pts
build up of pro-FLG decreasing stratum corneum
Serine protease excess*: downregulates lamellar bodies, decreasing lipid content in stratum corneum

*exacerbated by alkaline soaps!

Question 10

Atopic dermatitis presentation

Answer 10

Fleczema! in adults

extensor surfaces, face, chest in infants

Question 11

Herpes Simplex Supplements

Answer 11

LYSINE (3g/day) (po, can also do topical)
Vit C
Zinc (po and topical)

Question 12

Acne Vulgaris Pathophys

Answer 12

Inflammatory skin condition with open and closed comedones
Excess sebum production with decreased drained
bacterial colonization of skin
FoxO1: inhibits protein and lipid synthesis; Reduces sterol regulatory binding protein

Question 13

Atopic Derm Nutritional Tx

Answer 13

Elimination Diet. treat the gut! food sensitivities and leaky gut likely present.
increase Treg function, decrease Th2 response

**caution with reintroduction–rarely can precipitate anaphylaxis

Question 14

Psoriasis: Terrain

Answer 14

bowel toxemia: edotoxins and candida
liver function: Ps &laquo_space;alcohol
bile deficiency: so supplement!

Question 15

Psoriasis Nutritional Tx

Answer 15

Elimination Diet

Dysbiosis and Leaky Gut

Question 16

Herpes Simplex Nutritional Tx

Answer 16

Decrease ARG (chocolate, nuts, soy) and increase LYS
Reduce refined carbs

Question 17

Atopic Derm Nutritional Tx AVOID

Answer 17

Avoid histamine containing foods
alcohol, fermented foods
anchovies, smoked fish/meat
eggplant

Question 18

Acne Vulgaris Nutritional Tx

Answer 18

Anti-Inflammatory Diet, avoid trans fats, high in fiber and antioxidants
Milk reduction/avoidance
Elimination Diet in recalcitrant cases

Question 19

Rosacea Pathophys

Answer 19

Inflammatory condition with erythema and telangiectasia, papules and pustules; Rhinophyma
pathogenic effect of UV and heat
vascular dysregulation
excessive colonization by mites!

Question 20

Furunculosis Nutritional Tx

Answer 20

Refined carbohydrate restriction

Anti-inflammatory diet

Question 21

Atopic Derm Supplementation

Answer 21

FA supplementation. Flaxseed Oil; Combined EPA + DHA
Probiotics- L. rhamnosus
Glutamine (to decrease intestinal permeability)