4: Derm Flashcards
Psoriasis Pathophys
AI
keratinocyte hyperproliferation, increased angiogenesis, antimicrobial peptides
high genetic susceptibility
(high co-prevalence of Metabolic Syn)
Psoriasis Supplementation
Vit A, preformed- promotes Treg/suppresses Th17 Vit D Alpha lipoic acid EPA + DHA Fatty acids Zinc picolinate/citrate
Psoriasis Deficiencies
Vit A, Zn
GSH
Vit D
Rosacea Nutritional Tx
Elimination Diet
Anti-inflammatory Diet
Zinc
Lipase supplementation
Rosacea Triggers
alcohol, hot liquids, spicy foods
Furunculosis Risk Factors
deficits in hygiene, obesity, DM, other skin dz, prior abx tx, immunosuppressive tx, less personal sleeping space
Atopic Derm Tx
Within three minutes: SLATHER in salve (Lipid replacement- ceramide, FFA, cholesterol)
Acne Vulgaris supplements
Curcumin
Zinc
ECGC
Low-mod dose vitamin A
Atopic Derm Pathophys
Filaggrin deficiency
FLG: essential protein in epidermis; common mutation in AD pts
build up of pro-FLG decreasing stratum corneum
Serine protease excess*: downregulates lamellar bodies, decreasing lipid content in stratum corneum
*exacerbated by alkaline soaps!
Atopic dermatitis presentation
Fleczema! in adults
extensor surfaces, face, chest in infants
Herpes Simplex Supplements
LYSINE (3g/day) (po, can also do topical)
Vit C
Zinc (po and topical)
Acne Vulgaris Pathophys
Inflammatory skin condition with open and closed comedones
Excess sebum production with decreased drained
bacterial colonization of skin
FoxO1: inhibits protein and lipid synthesis; Reduces sterol regulatory binding protein
Atopic Derm Nutritional Tx
Elimination Diet. treat the gut! food sensitivities and leaky gut likely present.
increase Treg function, decrease Th2 response
**caution with reintroduction–rarely can precipitate anaphylaxis
Psoriasis: Terrain
bowel toxemia: edotoxins and candida
liver function: Ps «_space;alcohol
bile deficiency: so supplement!
Psoriasis Nutritional Tx
Elimination Diet
Dysbiosis and Leaky Gut
Herpes Simplex Nutritional Tx
Decrease ARG (chocolate, nuts, soy) and increase LYS Reduce refined carbs
Atopic Derm Nutritional Tx AVOID
Avoid histamine containing foods
alcohol, fermented foods
anchovies, smoked fish/meat
eggplant
Acne Vulgaris Nutritional Tx
Anti-Inflammatory Diet, avoid trans fats, high in fiber and antioxidants
Milk reduction/avoidance
Elimination Diet in recalcitrant cases
Rosacea Pathophys
Inflammatory condition with erythema and telangiectasia, papules and pustules; Rhinophyma
pathogenic effect of UV and heat
vascular dysregulation
excessive colonization by mites!
Furunculosis Nutritional Tx
Refined carbohydrate restriction
Anti-inflammatory diet
Atopic Derm Supplementation
FA supplementation. Flaxseed Oil; Combined EPA + DHA
Probiotics- L. rhamnosus
Glutamine (to decrease intestinal permeability)
