5. Acute Inflammation I Flashcards
Cardinal signs of Inflammation
\_\_\_\_ • \_\_\_\_ • \_\_\_\_ • \_\_\_\_ • \_\_\_\_
Heat, redness, swelling: ____
Pain: ____
Heat (calor) Redness (rubor) Swelling (tumor) Pain (dolor) loss of function
sign
symptom
Archiv für Pathologische Anatomie und Physiologie und für Klinische Medizin-1867
To a response of IRRITATION:
- ____ of arterioles and acceleration of blood flow
- Few min. later, WBC line the wall of the ____ (glued?)
- Some WBC crossed venules into extravascular space
- In some vessels, RBC tightly packed, decreased ____
- Loss of plasma
- ____ > Rubor (Redness)
- Increased ____ >Calor (Heat)
- Fluid ____ >Tumor (Swelling)
- Pain?
dilation
venules
blood flow
vasodilation
blood flow
exudation
• Phagocytosis: • Purpose of Inflammation; engulf bacteria and foreign matter • Increased vascular permeability: Allowed \_\_\_\_ along with \_\_\_\_ to participate in inflammation.
Used transparent invert’s and observed ingestion of particles > they would go around and eat the particle > phagocytosis
When same experiment was completed with frog leuokocytes > same mechanism of action
Purpose of inflammation: engulf and rid of foreign material/bacteria (Metchnikoff)
Ehrlich & Metchnikoff > knew there was loss of ____ > increased vascular permeability due to increased ____ resulting in a recruitment of leukocytes (and ab’s) from BV to EC space
antibodies
leukocytes
plasma
irritation
Inflammation:
Vascular and Cellular response when living tissues are injured or irritated
All of these lead to INFLAMMATION:
*____:
•Bacteria
•Virus
•Fungus
____:
• Rheum Arthritis
• Pemphigus Vulgaris
____:
(Physical/Chemical Injury)
____:
(Ischemia/Infarct)
____:
•Anaphylactic •Pollen/Insect
____:
•Splinters, dirt, sutures
•Urate crystals (Gout)
•Cholesterol Crystals (Atherosclerosis)
infection auto-immune tissue necrosis tissue necrosis immune/hypersen foreign bodies/endogenous
Purpose
- ____ off injurious agent
- Dilute/Destroy/eliminate the cause
- Limit tissue damage
- Remove dead cells and debris
- Initiate ____
- Return Tissue to ____.
Without Inflammation:
– Cannot Control ____
– Wound never ____
wall
healing
normal
infection
heals
Inflammation and healing
Steps In Inflammatory Response (5R’s): \_\_\_\_ of Injury \_\_\_\_ of Leukocytes \_\_\_\_ of Injurious agents \_\_\_\_ (Control) \_\_\_\_ (Repair/healing)
Acute Inflam Onset: \_\_\_\_ Cells: \_\_\_\_ Tissue Injury: \_\_\_\_ Local Effects: \_\_\_\_
Chronic Inflam Onset: \_\_\_\_ Cells: \_\_\_\_ Tissue Injury: \_\_\_\_ Local Effects: \_\_\_\_
recognition recruitment removal regulation resolution
minutes/hours
neutrophils
mild, self-limited
prominent (vascular)
days/months/years
“round”
severe progressive
less
Inflammation and healing
A stimulus is required: can come in form of microbial infection (epithelial cell serves as a physical barrier), or because of necrotic tissue
Next, injury must be recognized: completed by cells located just beneath the epithelium (macrophages, dendritic cells [APC], or mast cells, known as ____ in innate immunity)
Recruit leukocytes: sentinel cells communicated with BV by secreting mediators (the biggest difference among leukocytes: mast cells are packed with tons of granules, that are released ____ upon activation
Removal of injurious agent (phagocytosis), and regulation/control (tissue damage otherwise), and finally resolution/repair
sentinel/gate-keeping cells
instantaneously
Most oral diseases are inflammatory…
Acute Inflam • Dental Caries • *\_\_\_\_ • *\_\_\_\_ • *\_\_\_\_ • Ludwig’s Angina • Cavernous Sinus thrombosis • Meningitis • \_\_\_\_ • \_\_\_\_
Chronic Inflam • Acute/Chronic \_\_\_\_ • Pyogenic granuloma • Periapical cyst • Condensing Osteitis • Orofacial granulomatosis – Melkersson-Rosenthal syndrome – Cheilitis granulomatosa
pulpitis periapical abscess cellulitis gingivitis periodontitis
osteomyelitis
Incision in skin and there are three problems: ____, ____, and ____ (most important) > mount a response in order to maintain the infection locally
Firstly, recruit neutrophils, but they require supply: plasma > provides ____ (because neutrophils are not good “swimmers”), and they also provide ____ (important in getting rid of “them?”)
No inflammatory reaction > death; if you have one > you will have both a ____ and ____ response (acute inflammation) > neutrophils releasing mediators and ROS that will damage tissue > requires a healing process to conclude
What if infected with microbe that is difficult to rid > wound healing and ____ inflammation occur simultaneously > cannot heal adequately
bleeding
tissue loss
infection
fibrin meshwork
antibodies/complement
cellular
vascular
chronic
OUTCOME
• Nature of the Etiologic Agent
– Is the agent harmful? ____
– /Pollen/Peanut/self-component
• Intensity of the reaction – Proportional to etiology? – Controlled?
- Regenerative Potential
- Skin
- Brain, Myocradium
• Host status
- HIV, autoimmune
If individual’s are genetically predisposed > innocuous agents are recognized as harmful and the immune system reacts > creation of a problem (allergy and AID)
Skin > proliferative if damaged > return to ____
Brain/myocardium > no ____, and no regeneration > replaced by scar tissue (non-functional connective tissue)
HIV > individual may not be able to clear infection properly, but if body recognizes self-component as foreign > ____ inflammation
bacteria
normal
regenerative capacity
chronic
Inflammation occurs only in ____ tissue
Infarct > inflammation occurs ____ of the necrotic tissue (cannot have inflammation within dead tissue, but it can initiate a ____); what’s the purpose of this mechanism > ____ response in order to remove the necrotic tissue
living
outside
response
protective
50-70% of pregnant women develop gingivitis during ____ due to ____ control and extra-sensitivity to ____; important to floss and clean regularly
pregnancy
hormonal
infection
Arteriovenous shunt; precap sphincter closed > capillary bed not utilized, blood flows from arterial to venous end without the capillary bed
In normal situation (right slide) > these sphincters ____ and close intermittently, utilizing specific parts of the ____
open
capillary beds
Mast cells located just below the epithelium, no matter the tissue, and they are universally found close to a ____
Release ____ > contract smooth muscle > dilation and gushing in of blood > and all the sphincters ____ > formation of a “20-way” highway
[Initial ____?]
How about tissue swelling? This contributes to tissue swelling because the blood remains within the BV; if there was no leakage there would not be swelling
Hyperemia: increased ____ within tissue
reflex vasoconstriction
Tissue Swelling
Normal: as blood flows > hydrostatic pressure; the squamous cell type is semi-permeable (fluid and electrolyte, but not to protein), because of the HP fluid traverses the membrane into EC space, as a result there’s formation of an ____, and as a result > you get fluid going back into the tissue > there is ____ (more fluid leaves than reenters); the factor that puts it into balance > ____ system
____ > if fluid is exiting, this exit is balanced by the inflow of fluid back in and into the lymphatic > no swelling
osmotic pressure
imbalance
lymphatic
starling’s law
Lymphatic vessels
• Collects lymph from ____
• Delivers it to the ____
• Returns fluid to circulatory veins near the ____
lymph capillaries
nodes
heart
Starling’s Law
During inflammation: epithelial cells now become permeable to ____ > (albumin smaller than fibrinogen) > these factors leak out into the EC > ____ is lower > lymphatics tries to balance but is unable to do so
Swelling > because of increased ____ to protein
protein
osmotic pressure
vascular permeability
