4.7 Components Flashcards
A male patient with cancer was admitted to the hospital with acute abdominal pain and a hemoglobin level of 6 g/dL. Small bowel resection was indicated, but the attending physician wanted to raise the patient’s hemoglobin level to 12 g/dL before surgery. How many units of RBCs would most likely be required to accomplish this?
6
Which of the following is not a viable method for removing leukocytes from RBCs?
A. Prestorage filtration
B. Bedside filtration
C. Poststorage filtration
D. Buffy coat removal
Buffy coat removal
Four units of packed RBCs were brought to the nurses’ station at 10:20 a.m. Two units were transfused immediately, and 1 unit was transfused at 10:40 a.m. The remaining unit was returned to the blood bank at 11:00 a.m. The units were not refrigerated after leaving the blood bank. What problem(s) is (are) present in this situation?
The only problem is with the returned unit; the 30-minute limit has expired and the unit cannot be used
A unit of whole blood is collected at 10:00 a.m. and stored at 20°C to 24°C. What is the last hour at which platelet concentrates may be made from this unit?
6:00 p.m.
Which of the following is acceptable according to the AABB standards?
A. Rejuvenated RBCs may be made within 3 days of outdate and transfused or frozen within 24 hours of rejuvenation
B. Frozen RBCs must be prepared within 30 minutes of collection and may be used within 10 years
C. Irradiated RBCs must be treated within 8 hours of collection and transfused within 6 hours
D. Leukocyte-reduced RBCs must be prepared within 6 hours of collection and transfused
Rejuvenated RBCs may be made within 3 days of outdate and transfused or frozen within 24 hours of rejuvenation
Which of the following is true regarding apheresis platelets?
A. The minimum platelet count must be 3.0 × 10^11, pH must be 6.0 or greater
B. The minimum platelet count must be 3.0 × 10^10, pH must be 6.2 or less
C. The minimum platelet count must be 3.0 × 10^11, pH must be 6.2 or greater
D. The minimum platelet count must be 5.5 × 10^10, pH must be 6.0 or less
The minimum platelet count must be 3.0 × 10^11, pH must be 6.2 or greater
What is the component of choice for a patient with chronic granulomatous disease (CGD)?
Granulocytes
What method can be employed to detect bacteria in random donor platelets?
Pan-genera detection (PGD) assay
All of the following statements regarding FFP are true, except:
A. FFP must be prepared within 24 hours of collection
B. After thawing, FFP must be transfused within 24 hours
C. Storage temperature for FFP with a 1-year shelf life is –18°C or less
D. When thawed, FFP must be stored between 1°C to 6°C
FFP must be prepared within 24 hours of collection
What may be done to RBCs before transfusion to a patient with cold agglutinin disease to reduce the possibility of a transfusion reaction?
Warm to 37°C with a blood warmer
A unit of packed RBCs is split using the open system. One of the half units is used. What may be done with the second half unit?
Must be issued within 24 hours
What should be done if a noticeable clot is found in an RBC unit?
Do not issue the unit
Cryoprecipitate may be used to treat all of the following, except:
A. von Willebrand disease
B. Hypofibrinogenemia
C. Idiopathic thrombocytopenic purpura (ITP)
D. Factor XIII deficiency
Idiopathic thrombocytopenic purpura (ITP)
SITUATION: A transplant patient may receive only type A or AB platelets. Only type O apheresis platelets are available. What devices may be used to deplete the incompatible plasma and replace with sterile saline?
Centrifuge/sterile connecting device
What component(s) is (are) indicated for patients who have anti-IgA antibodies?
Washed or deglycerolized RBCs
What is the expiration date for pooled cryoprecipitate (pooled before freezing)?
12 months from earliest date of collection of product in pool
All of the following are true regarding washed RBCs, except:
A. RBCs are washed with 1 to 2 L of normal saline
B. Volume is 180 mL
C. Shelf life is extended
D. Leukocytes are removed
Shelf life is extended
What is a special condition for the storage of platelets?
Platelets require constant agitation at 20°C to 24°C
Transfusion of an irradiated product is indicated in all of the following conditions except:
A. Exchange transfusion
B. Bone marrow transplantation
C. Severe combined immunodeficiency syndrome (SCIDS)
D. Warm autoimmune hemolytic anemia
Warm autoimmune hemolytic anemia
What percentage of RBCs must be retained in leukocyte-reduced RBCs?
85%
Which of the following is true regarding granulocyte concentrates?
A. The product must contain a maximum of 1.0 × 1010 granulocytes
B. pH must be 6.0
C. The product must be crossmatched
D. The product must be irradiated
The product must be crossmatched
What course of action should be taken if an MLS inadvertently irradiates a unit of
RBCs twice?
Discard the unit
What components(s) may be shipped together with FFP?
Frozen RBCs and cryoprecipitate
A blood supplier ships 3 units of pooled cryoprecipitate. Each pool consists of 5 units of cryoprecipitate. If one unit is thawed at 5:00 p.m., when must it be dispensed from the blood bank?
Before 9:00 p.m.
How does irradiation prevent transfusion-associated graft-versus-host disease (TA- GVHD)?
Gamma rays and x-rays destroy the lymphocytes’ ability to divide
Which component has the longest expiration date?
A. Cryoprecipitate
B. FFP
C. Frozen RBCs
D. Platelet concentrates
Frozen RBCs
All of the following are advantages of using single-donor platelets as opposed to random donor platelets, except:
A. Less preparation time
B. Less antigen exposure for patients
C. May be HLA matched
D. No pooling is required
Less preparation time
What is the expiration of cryoprecipitate once pooled without the use of a sterile
connecting device?
4 hours
What is the number of WBCs permitted in a unit of leukocyte-reduced RBCs?
Less than 5 × 10^6
SITUATION: A patient with cancer recently developed a severe infection. The patient’s hemoglobin level is 8 g/dL as a result of chemotherapy with a drug known to cause bone marrow depression and immunodeficiency. Which blood products are indicated for this patient?
Irradiated RBCs, platelets, and granulocytes
