4.1 Genetics And Immunology Of Blood Groups

Question 1

What type of serological testing does the blood bank technologist perform when determining the blood group of a patient?

Answer 1

Phenotyping

Question 2

If anti-K reacts 3+ with a donor cell with a genotype KK and 2+ with a Kk cell, the antibody is demonstrating:

Answer 2

Dosage

Question 3

Carla expresses the blood group antigens Fya, Fyb, and Xga. James shows expressions of none of these antigens. What factor(s) may account for the absence of these antigens in James?

Answer 3

Gender and Race

Question 4

Which of the following statements is true?
A. An individual with the BO genotype is homozygous for B antigen
B. An individual with the BB genotype is homozygous for B antigen
C. An individual with the OO genotype is heterozygous for O antigen
D. An individual with the AB phenotype is homozygous for A and B antigens

Answer 4

B. An individual with the BB genotype is homozygous for B antigen

Question 5

Which genotype is heterozygous for C?
A. DCe/dce
B. DCE/DCE
C. Dce/dce
D. DCE/dCe

Answer 5

A. DCe/dce

Question 6

Which genotype(s) will give rise to the Bombay phenotype?
A. HH only
B. HH and Hh
C. Hh and hh
D. hh only

Answer 6

D. hh only

Question 7

Meiosis in cell division is limited to the ova and sperm producing four gametes containing what complement of DNA?

Answer 7

1N

Question 8

A cell that is not actively dividing is said to be in:

Answer 8

Interphase

Question 9

Which of the following describes the expression of most blood group antigens?
A. Dominant
B. Recessive
C. Codominant
D. Corecessive

Answer 9

C. Codominant

Question 10

What blood type is NOT POSSIBLE for the offspring of an AO and BO mating: AB, A or B, O, all are possible

Answer 10

All are possible

Question 11

The alleged father of a child in a disputed case of paternity is blood group AB. The mother is group O, and the child is group O. What type of exclusion is this?

Answer 11

Indirect/Secondary/Second Order

Question 12

If the frequency of gene Y is 0.4 and the frequency of gene Z is 0.5, one would expect that they should occur together 0.2 (20%) of the time. In actuality, they are found together 32% of the time. This is an example of:

Answer 12

Linkage Disequilibrium

Question 13

In the Hardy-Weinberg formula, p^2 represents ______

Answer 13

The homozygous population of one allele

Question 14

In this type of inheritance, the father carries the trait on his X chromosome. He has no sons with the trait because he passed his Y chromosome to his sons; however, all his daughters will express the trait.

Answer 14

X-Linked Dominant

Question 15

Why do immunoglobulin M (IgM) antibodies, such as those formed against ABO antigens, have the ability to directly agglutinate RBCs and cause visible agglutination?

Answer 15

IgM antibodies are larger molecules that have the ability to bind more antigen

Question 16

Which of the following enhancement mediums decreases the zeta potential, allowing antibody and antigen to come closer together?

Answer 16

Low Ionic Strength Solution (LISS)

Question 17

This type of antibody response is analogous to an anamnestic antibody reaction.

Answer 17

Secondary

Question 18

Which antibodies to a component of complement are contained in the rabbit polyspecific anti-human globulin (AHG) reagent for detection of in vivo sensitization?

Answer 18

Anti-IgG and anti-C3d