43 - Hepatitis

Question 1

inflammation of the liver is often caused by… + less often caused by..

Answer 1

virus

substance abuse, autoimmune disease, metab problems

Question 2

Hep B
incubation

Answer 2

115-180 days
avg 56-96

Question 3

Hep B mode of transmittion

Answer 3

-sex
-perinatal
-percutaneous/parenteral or mucosal exposure to BLOOD or BLOOD PRODUCTS

Question 4

Hep B source of infection

Answer 4

-contaminated needles, syringes, blood products
-HBV infected mom
-sex
-tattoos/piercings

Question 5

Hep B infectivity

Answer 5

-infectious for months
-before + after symptoms appear
-carriers continue to be infectious for life

Question 6

Hep A transmission

Answer 6

fecal-oral

Question 7

Hep C transmission

Answer 7

same as B
SEX, BEEDLES, BLOOD PRODUCTS
PERINATAL CONTACT

Question 8

Hep D is fr

Answer 8

progression of chronic carriers of Hep B

Question 9

Hep E transmission

Answer 9

fecal-oral
-contaminated water
-poor sanitation
-3rd world

Question 10

Hep A is self limiting
T/F?

Answer 10

triue

Question 11

acute vs chronic hepatitis

Answer 11

acute can still regenerate
chronic can be insiduous, can cause fibrosis/scarring, can lead to cirrhosis (irreversible)

Question 12

Hep C
incubation

Answer 12

14-180 days (average 56 days)

Question 13

Hep C infectivity

Answer 13

-1-2 wk before s/s appear
-cont during clinical course

Question 14

75-85% Acute Hep C can develop….

Answer 14

chronic Hep C

can remain infectious

Question 15

most common cause of chronic liver disease

Answer 15

HEP C

Question 16

pt w ___ are at a higher risk of getting Hep C

Answer 16

HIV

Question 17

Hep C acute manifestations

Answer 17

 Pain in the upper right quadrant of abdomen
 Nausea and vomiting
 Loss of appetite
 Jaundice
-pruritus
 Fatigue
-flu like symptoms

Question 17

Hep C acute manifestations

Answer 17

 Pain in the upper right quadrant of abdomen
 Nausea and vomiting
 Loss of appetite
 Jaundice
-pruritus
 Fatigue
-flu like symptoms

Question 17

Hep C acute manifestations

Answer 17

 Pain in the upper right quadrant of abdomen
 Nausea and vomiting
 Loss of appetite
 Jaundice
-pruritus
 Fatigue
-flu like symptoms

Question 17

Hep C acute manifestations

Answer 17

 Pain in the upper right quadrant of abdomen
 Nausea and vomiting
 Loss of appetite
 Jaundice
-pruritus
 Fatigue
-flu like symptoms

Question 18

Chronic Manifestations Hep C

Answer 18

-elevated ALT/AST
-ascites, edema
-asterixis (liver flap)
-bleed abnorm
-hep encephalopathy
-incr bilirubin

Question 19

hepatic encephalopathy

Answer 19

potentially life threatening neuro, psych, motor disturbances
>fr inability of liver to remove toxins esp ammonia

Question 20

hepatic encephalopathy signs

Answer 20

confusion
difficulty concentrating
agitation

Question 21

ascites occurs fr…

Answer 21

reduced protein levels which reduces oncotic pressure

Question 22

test marker for acute hep c

Answer 22

anti-HCV
aka antibody for HCV

Question 23

Combo therapy for HCV

Answer 23

elbasvir + grazoprevir
Pibrentasvir + glecaprevir
HARVONI

Question 24

HARVONI

Answer 24

combo therapy for HCV

ledipasvir + sofosbuvir