4.1 Protein Structure and Function

Question 1

What are native confromations

Answer 1

protein structure having biological activity

Question 2

What is the primary structure

Answer 2

the order in which aa are covalently linked together. 1_D first step in specifying 3-D structure of protein

Question 3

What is the Secondary structure

Answer 3

Ordered patterns of 3-D arrangement of localized regions of peptide backbone. repetitive interaxn resulting from H2 bonding btwn N-H and carbonyl group of backbone

Question 4

What are some types of secondary structure

Answer 4

alpha helix and beta pleated sheets

Question 5

What are domains or supersecondary structure

Answer 5

folding of parts of the chain can occur independently of the folding of other parts

Question 6

What is the tertiary structure

Answer 6

complete 3-D arrangement of all atoms in protein, including those in side chains, and prosthetic groups

Question 7

What is the quaternary structure

Answer 7

multiple polypeptide chains called subunits that arrange wrt one another

Question 8

What are interaxn btwn subunits mediated by

Answer 8

noncovalent interaxns: H2 bonds, electrostatic attraction and hydrophobic interaxn