4 - Stress/Coping, Addiction, Behavioral Pain Flashcards
(Pain)
Two Main Pathways
Sensory/Discriminative Pain = Where
Affective-Motivational Pain = How much pain*
*Detrimental during chronic situations
(Pain)
Periaqueductal Gray
Modulate pain
(Pain)
Amygdala
Anxiety in psychiatry, fight or flight, etc.
(Pain)
Modulation Pathway
Periaqueductal Gray
I
Dorsal Raphe Nucleus (Serotonin)
I
- Ascending to Thalamus
- Descening to Spinal Cord (turn down pain signal)
(Pain)
Allodynia
Hyperalgesia
Allodynia - Painful non-noxious stimuli
Hyperalgesia - Mildly painful stimuli become much more painful
SUNBURN:
Allodynia = putting on your shirt
Sunburn gives you Hyperalgesia
(Pain)
Pain Tolderance Spectrum
Motivation Pathways ?
Increased Activation ?
Anterior Cingulate Cortex (ACC), PreFrontal Cortex (PFC)
Somatosensory Cortex
(Pain)
What gene may govern pain sensitivity?
COMT
(Pain)
What areas of brain play a role in Placebo?
Dorsolateral Prefrontal Cortex - Cognitive Control
Orbitofrontal Cortex - Evaluative/Reward
Periaqueductal Gray - Enkephalin neurons, modulation of dorsal raphe nucleus (serotonin–down regulate pain)
(Pain)
Stress-Induced Analgesia
Under extreme stress, pain sensors can be shut down
(Pain)
Chronic Pain
Neuropathic Pain dervies from nerve injury, not tissue damage
(Pain)
Pain Memory - Phantom Pain
After amputation, patients sometimes continue to experience pain that was present prior to the surgery
Local anesthesia in affected limb prior to surgery can help
(Pain)
Gray Matter Loss
Chronic pain can cause brain atrophy; hinder ability to down regulate pain
(Pain)
Early vs Late Stages of Pain
Early: Acute, Fear, Anxiety
Middle: Learned helplessness, depression, anger, substance abuse
Late: Acceptance of “sick role”, excused from socual obligations
(Pain)
Depression & Antidepressants
Target Serotonin / Norepinephrine
(Pain)
Addiction in Patients with Pain
Those in pain are vulnerable to addiction, esp. Optiates, gain addiction following trauma