4. Microfilaments Flashcards

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1
Q

Diameter of microfilaments

A

7-9 nm

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2
Q

Actin monomer binding proteins

A

Profilin

Thymosin beta

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3
Q

Straight filament nucleators

A

formin

Spire

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4
Q

Branched filament nucleators

A

Arp2/Arp3 complex

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5
Q

Filament capping proteins, plus end

A

CapZ

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6
Q

Filament capping proteins, minus end

A

Tropomodulin

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7
Q

Filament severing proteins

A

ADF-cofilin

Severin

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8
Q

Filament side binding stabilisers

A

Tropomodulin

Nebulin

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9
Q

Bundling proteins

A

Fibrin

alpha-actinin

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10
Q

Cross-linking proteins

A

Filamin

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11
Q

Membrane linkers

A

Spectrin

Dystrophin

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12
Q

Motors

A

Myosins

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13
Q

Examples of drugs/toxins to study actin

A
Cytochalasin B D
Tolytoxin
Latrunculin A
Phalloidin
Botulinum toxin
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