4. Intro to Renal BF - DSA

Question 1

In what order does fluid pass through the layers to be filtered?

Answer 1

Capillary lumen –> capillary endothelium –> glomerular basement membrane –> podocyte epithelium –> bowman’s capsule

Question 2

Biogel

Answer 2

lines the capillary lumen - made of glomerular endothelium glycolayx.

Glycolayx has sialated glycoproteins, hyaluronan, and heparan sulfate. will be bound to the glomerular basement membrane

Question 3

Nephrin

Answer 3

CAM for glomerulus filtration slits. very good for filtration bc has a size restriction

P-cadherin and a-actinin are also CAMs for filtration slits

Question 4

What size molecules are freely filtered through filtration slits? Not filtered?

Answer 4

<20 A

>42 A

Question 5

What happens if you remove the negative charge barrier form the filtration barrier?

Answer 5

Influx of anions –> can lead to protein urea

Question 6

Filtered load equation

Answer 6

[Plasma of X) x GFR

Represents amt. of substance filtered into bowman’s space per unit of time

Question 7

Urinary excretion equation

Answer 7

Amount filtered - amount reabsorbed + amount secreted