4: Eye in systemic disease Flashcards

1
Q

How does hyperglycaemia cause retinopathy in uncontrolled diabetes?

A

Glycosylation of basement membrane

Loss of pericytes (muscle cells which hold endothelium together)

Microaneurysm - LEAKAGE and ISCHAEMIA

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2
Q

Why do people with diabetic retinopathy lose their vision?

A

Retinal oedema over fovea

Vitreous haemorrhage

Retinal detachment

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3
Q

How is diabetic retinopathy managed?

A

Manage condition - blood pressure, glycaemic control

Laser therapy - panretinal photocoagulation, sacrifices peripheral retina to stop new blood vessel formation

Anti-VEGF injections

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