4: Eye in systemic disease Flashcards
1
Q
How does hyperglycaemia cause retinopathy in uncontrolled diabetes?
A
Glycosylation of basement membrane
Loss of pericytes (muscle cells which hold endothelium together)
Microaneurysm - LEAKAGE and ISCHAEMIA
2
Q
Why do people with diabetic retinopathy lose their vision?
A
Retinal oedema over fovea
Vitreous haemorrhage
Retinal detachment
3
Q
How is diabetic retinopathy managed?
A
Manage condition - blood pressure, glycaemic control
Laser therapy - panretinal photocoagulation, sacrifices peripheral retina to stop new blood vessel formation
Anti-VEGF injections