1: Assessing evidence in medicine

Question 1

Why do studies need an ethical framework?

Answer 1

If unregulated people are put at risk / die or data can be manipulated for $$$

see thalidomide and birth defects

Question 2

What is the Declaration of Helsinki?

Answer 2

“It is the duty of physicians who are involved in medical research to protect the life, health, dignity, integrity, right to self-determination, privacy, and confidentiality of personal information of research subjects.”

tl;dr look after the people in your studies

Question 3

The Declaration of Helsinki states that groups which are underrepresented in medical research must be provided with access to studies.

Which group is a good example of this?

Answer 3

Elderly

because population is aging and data is very useful, but elderly recruitment is low

Question 4

What is publication bias?

Answer 4

Studies which non-significant results aren’t published as much as those with significant results

bad science ben goldacre

Question 5

Which act describes the rules researches have to follow when they have people’s personal info?

Answer 5

Data Protection Act

Question 6

What is a Caldicott Guardian?

Answer 6

Person employed by the NHS who is responsible for enforcing data protection rules

Question 7

consent is important in research

does this surprise you